68795-37-9Relevant academic research and scientific papers
Methylation of cyanidin-3-o-glucoside with dimethyl carbonate
Brehmer, Tillman,Passon, Maike,Schieber, Andreas,Stra?mann, Sarah
, (2021)
The approach presented in this study is the first for the hemisynthesis of methylated anthocyanins. It was possible to obtain cyanidin-3-O-glucoside derivatives with different degrees of methylation. Cautious identification of 4'-, 5-, and 7-OH monomethylated derivatives was also accomplished. The methylation agent used was the “green chemical” dimethyl carbonate (DMC), which is characterized by low human and ecological toxicity. The influence of the temperature, reaction time, and amount of the required diazabicyclo[5.4.0]undec-7-en (DBU) catalyst on the formation of the products was examined. Compared to conventional synthesis methods for methylated flavonoids using DMC and DBU, the conditions identified in this study result in a reduction of reaction time, and an important side reaction, so-called carboxymethylation, was minimized by using higher amounts of catalyst.
Enzymatic hemisynthesis of metabolites and conjugates of anthocyanins
Fernandes, Iva,Azevedo, Joana,Faria, Ana,Calhau, Conceicao,Freitas, Victor De,Mateus, Nuno
experimental part, p. 735 - 745 (2010/07/15)
This work aims to study the phase II metabolization of anthocyanins that is likely to occur in vivo. Anthocyanins (delphinidin, cyanidin, and malvidin-3-glucosides) were incubated with phase II enzymes in the presence of activated cofactors in order to ob
