68797-51-3Relevant articles and documents
Copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as ligand and synthesis method of copper compound
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Paragraph 0046-0050, (2020/03/06)
The invention discloses a copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as a ligand and a synthesis method of the copper compound. The synthesis method comprises the following steps: adding thiosemicarbazone into absolute ethyl alcohol, performing stirring and dissolution, adding 2-thiophenecarboxaldehyde, performing uniform mixing, stirring the mixed solution at 70 DEG C in awater bath, performing volatilization at room temperature, separating a crystal so as to obtain a ligand; and adding the prepared ligand into absolute ethyl alcohol, performing stirring and dissolving, adding CuBr2.2H2O after dissolution, performing stirring at 70 DEG C in a water bath, performing volatilization at room temperature, and separating out a crystal, so as to obtain a Cu compound of the ligand. An in-vitro proliferation inhibition activity experiment is further carried out on the synthesized copper compound, results show that the synthesized series of copper compounds have generally good in-vitro activity, particularly have high specificity on human T24 and HeLa cells, show good inhibitory activity, have little toxic effect on human normal cells, and are suitable for preparingefficient and low-toxicity anti-tumor drugs.
