68797-51-3

Usage

InChI:InChI=1/C7H13NO2S2.Na/c1-3-8(4-2)7(11)12-5-6(9)10;/h3-5H2,1-2H3,(H,9,10);/q;+1/p-1

Upstream product

• 3926-62-3 sodium monochloroacetic acid 
• 148-18-5 sodium N,N-diethyldithiocarbamate 

Downstream Products

• 21198-48-1 4,4-diethyl-thiosemicarbazide 

Relevant academic research and scientific papers

Copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as ligand and synthesis method of copper compound

The invention discloses a copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as a ligand and a synthesis method of the copper compound. The synthesis method comprises the following steps: adding thiosemicarbazone into absolute ethyl alcohol, performing stirring and dissolution, adding 2-thiophenecarboxaldehyde, performing uniform mixing, stirring the mixed solution at 70 DEG C in awater bath, performing volatilization at room temperature, separating a crystal so as to obtain a ligand; and adding the prepared ligand into absolute ethyl alcohol, performing stirring and dissolving, adding CuBr2.2H2O after dissolution, performing stirring at 70 DEG C in a water bath, performing volatilization at room temperature, and separating out a crystal, so as to obtain a Cu compound of the ligand. An in-vitro proliferation inhibition activity experiment is further carried out on the synthesized copper compound, results show that the synthesized series of copper compounds have generally good in-vitro activity, particularly have high specificity on human T24 and HeLa cells, show good inhibitory activity, have little toxic effect on human normal cells, and are suitable for preparingefficient and low-toxicity anti-tumor drugs.

Single-crystal structure and intracellular localization of Zn(II)-thiosemicarbazone complex targeting mitochondrial apoptosis pathways

Tracking of drugs in cancer cells is important for basic biology research and therapeutic applications. Therefore, we designed and synthesised a Zn(II)-thiosemicarbazone complex with photoluminescent property for organelle-specific imaging and anti-cancer proliferation. The Zn(AP44eT)(NO3)2 coordination ratio of metal to ligand was 1:1, which was remarkably superior to 2-((3-aminopyridin-2-yl) methylene)-N, N-diethylhydrazinecarbothioamide (AP44eT·HCl) in many aspects, such as fluorescence and anti-tumour activity. Confocal fluorescence imaging showed that the Zn(AP44eT)(NO3)2 was aggregated in mitochondria. Moreover, Zn(AP44eT)(NO3)2 was more effective than the metal-free AP44eT·HCl in shortening the G2 phase in the MCF-7 cell cycle and promoting apoptosis of cancer cells. Supposedly, the effects of these complexes might be located mainly in the mitochondria and activated caspase-3 and 9 proteins.