6880-16-6

Basic information

• Product Name: Benzeneethanol, a-1-propynyl-
• CAS NO: 6880-16-6
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 6880-16-6.mol

Chemical Properties

• Boiling Point: 125-126 °C(Press: 28 Torr)
• Density: 0.9987 g/cm3
• CAS DataBase Reference: Benzeneethanol, a-1-propynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, a-1-propynyl-(6880-16-6)
• EPA Substance Registry System: Benzeneethanol, a-1-propynyl-(6880-16-6)

Safety Data

• Hazardous Substances Data: 6880-16-6(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 74-99-7 prop-1-yne 
• 106-96-7 propargyl bromide 
• 16466-97-0 1-propynylmagnesium bromide 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 110079-64-6 1-phenyl-2-phthalimidopent-3-yne 
• 141543-29-5 1-phenyl-3-propyn-2-yl N-phenylurethane 
• 91820-11-0 1-Phenyl-2-chlor-pentin-⁽³⁾ 
• 141543-36-4 (E)-2--5-phenylpent-3-ene 
• 141543-38-6 (Z)-1-phenyl-3-propen-2-yl N-phenylurethane 
• 141543-37-5 [1-(2-Benzyl-cyclopropyl)-ethyl]-dimethyl-phenyl-silane 
• 110079-65-7 1-phenyl-2-aminopent-3-yne 
• 110079-70-4 N-((Z)-1-phenylpent-3-en-2-yl)benzamide 
• 110079-82-8 <4(R^*,S^*),5(R^*,S^*),6(S^*,R^*)>-2-phenyl-4-benzyl-5-hydroxy-6-methyl-5,6-dihydro-1,3-4H-oxazine 
• 110079-66-8 (Z)-1-phenyl-2-aminopent-3-ene 
• 110079-71-5 N-carbomethoxy-(Z)-1-phenyl-2-aminopent-3-ene 
• 110079-78-2 N-carbomethoxy-arabino-2-amino-3,4-epoxy-1-phenylpentane 
• 110169-89-6 N-carbomethoxy-ribo-2-amino-3,4-epoxy-1-phenylpentane 
• 110079-77-1 N-(arabino-3,4-epoxy-1-phenylpent-2-yl)benzamide 

Relevant articles and documents

Stereospecific Synthesis of cis-2,5-Disubstituted Pyrrolidines via N, O-Acetals Formed by Hydroamination Cyclization-Hydroalkoxylation of Homopropargylic Sulfonamides in HFIP

We reported a novel two-step stereoselective synthesis of functionalized pyrrolidines from homopropargylic sulfonamides and nucleophiles via an isolable N,O-acetal intermediates. This reaction features mild conditions and good scope of substrates. In addition, the use of hexafluoroisopropanol, acting as a solvent, an additive, a weak nucleophile, and a good leaving group, is pivotal to the success of the method. Moreover, reactions of chiral homopropargylic sulfonamides afford only 2,5-cis-disubstituted pyrrolidines with high diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to >99% ee). The overall reaction constitutes a formal 1,1-bifunctionalization of terminal alkynes, which has hitherto been reported only rarely. Additionally, this method provides efficient access to pharmaceutical intermediate and to carry out postmodification of natural products.

Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon

Herein, rhodium(III)-catalyzed C-H activation/subsequent [4 + 1] cyclization reactions between benzamides and propargyl alcohols are reported in which propargyl alcohols serve as unusual one-carbon units. This title transformation led to a series of isoin

3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES

This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives

Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): STR1 wherein: A is --C C--, trans --HC=CH--, trans --CH=CHCH2 -- or --CH2 CH2 --; X is lower alkyl of 1-6 carbon atoms; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); n is an integer from 2-4; R1 is --CH2 OH, --CHO, --CO2 R or --CO2 H, and the olefin formed by the R1 (CH2)n CH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally --CH=CH2 when A is trans --CH=CHCH2 --; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, STR2 --(CH2)m -phenyl or CH2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen. in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is STR3 wherein X' is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, or a pharmaceutically acceptable, non-toxic salt or ester thereof.

Stereochemistry of the Epoxidations of Acyclic Allylic Amides. Applications toward the Synthesis of 2,3,6-Trideoxy-3-aminohexoses

The stereochemistry of the epoxidation of several acyclic allylic amides is described.Diastereoselectivity in the (Z)-allylic amide series (compound 1) proved to be dependent both on the amide functionality and epoxidation reagent.The threo epoxide 3 was