6880-91-7 Usage
Uses
Used in Antimicrobial Applications:
Dihydrochelerythrine is used as an antimicrobial agent for its effectiveness against S. aureus, S. faecalis, and C. albicans, with a minimum inhibitory concentration (MIC) of 1.87 μg/ml for all.
Used in Antiviral Applications:
Dihydrochelerythrine is used as an antiviral agent, specifically inhibiting the secretion of hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells, with IC50 values of less than 0.05 μM for both.
Used in Anticancer Applications:
Dihydrochelerythrine is used as an anticancer agent, exhibiting cytotoxicity against various cancer cell lines such as HCT8, BGC-823, and A2780, with IC50 values of 1.4, 0.4, and 3.5 μM, respectively.
Used in Pharmaceutical Research:
Dihydrochelerythrine is synthesized as a potential G-quadruplex DNA stabilizing agent, which can be utilized in the development of new drugs targeting specific genetic sequences.
Used in Pharmacokinetic Studies:
Dihydrochelerythrine is used in pharmacokinetic studies of chelerythrine metabolites in agro-products, aiding in understanding the absorption, distribution, metabolism, and excretion of these compounds in the body.
Check Digit Verification of cas no
The CAS Registry Mumber 6880-91-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,8 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6880-91:
(6*6)+(5*8)+(4*8)+(3*0)+(2*9)+(1*1)=127
127 % 10 = 7
So 6880-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H19NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-9H,10-11H2,1-3H3
6880-91-7Relevant academic research and scientific papers
Chemical Transformation of Protoberberines. Part 9. A Biomimetic Synthesis of Oxychelerythrine, Dihydrochelerythrine, and Chelerythrine from Berberine
Hanaoka, Miyoji,Motonishi, Toshio,Mukai, Chisato
, p. 2253 - 2256 (2007/10/02)
Fully aromatised benzophenanthridine alkaloids, oxychelerythrine (4), dihydrochelerythrine (9), and chelerythrine (10) have been efficiently synthesized from berberine (1), a protoberberine alkaloid, via oxidative C(6)-N bond cleavage, followed by recyclisation betwen the C-6 and C-13 positions of (1) by a biogenetic process.
A Biomimetic Conversion of Berberine into Chelerythrine and Dihydrochelerythrine
Hanaoka, Miyoji,Motonishi, Toshio,Mukai, Chisato
, p. 718 - 719 (2007/10/02)
A novel and efficient synthesis of the benzophenanthridine alkaloids, chelerythrine and dihydrochelerythrine, from berberine was developed via a biogenetic route.
