6880-91-7 Usage
Description
Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).
Uses
Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.
Check Digit Verification of cas no
The CAS Registry Mumber 6880-91-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,8 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6880-91:
(6*6)+(5*8)+(4*8)+(3*0)+(2*9)+(1*1)=127
127 % 10 = 7
So 6880-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H19NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-9H,10-11H2,1-3H3
6880-91-7Relevant articles and documents
Chemical Transformation of Protoberberines. Part 9. A Biomimetic Synthesis of Oxychelerythrine, Dihydrochelerythrine, and Chelerythrine from Berberine
Hanaoka, Miyoji,Motonishi, Toshio,Mukai, Chisato
, p. 2253 - 2256 (2007/10/02)
Fully aromatised benzophenanthridine alkaloids, oxychelerythrine (4), dihydrochelerythrine (9), and chelerythrine (10) have been efficiently synthesized from berberine (1), a protoberberine alkaloid, via oxidative C(6)-N bond cleavage, followed by recyclisation betwen the C-6 and C-13 positions of (1) by a biogenetic process.
Biosynthesis of benzo[c]phenanthridine alkaloids sanguinarine, chelirubine and macarpine
Takao,Kamigauchi,Okada
, p. 473 - 484 (2007/10/02)
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