68802-01-7

Basic information

• Product Name: N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex
• Synonyms: N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex
• CAS NO: 68802-01-7
• Molecular Weight: 607.66
• Mol File: 68802-01-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex(68802-01-7)
• EPA Substance Registry System: N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex(68802-01-7)

Safety Data

• Hazardous Substances Data: 68802-01-7(Hazardous Substances Data)

Upstream product

• 1152-61-0 N-Cbz-L-Asp 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 4515-21-3 N-benzyloxycarbonylaspartic acid 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 33605-72-0 N-carbobenzyloxy-L-aspartyl-L-phenylalanine methyl ester 

Relevant articles and documents

Immobilized thermolysin and synthesis of precursor of aspartame

The optimal condition of the thermolysin-catalysed condensation reaction of N-benzyloxycarbonyl-DL-aspartic acid (Z-DL-Asp) with DL-phenylalanine methyl ester (DL-Phe-OMe) giving N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester, the precursor of the synthetic sweetener (aspartame, APM) has been investigated.The immobilized thermolysins have been prepared using seven polymethacrylate derivatives as carrier by covalent coupling of the polymers with enzyme.Seven derivatives have been synthesized using methacrylic acid, p-hydroxybenzoic acid and thecorresponding activated amide or amine.The abilities of the immobilized thermolysis to catalyze the condensation reaction have been tested and 100percent yield has been obtained by using one of them.