68802-35-7

Upstream product

• 1738-68-7 Gly-OBz 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 100-51-6 benzyl alcohol 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 

Downstream Products

• 98477-99-7 Z(OMe)-Ala-Asp(OBzl)-Gly-OBzl 
• 1421865-85-1 C₃₀H₃₄N₇O₁₀P 
• 101559-54-0 benzyl (3S)-3-amino-4-{[2-(benzyloxy)-2-oxoethyl]amino}-4-oxobutanoate trifluoroacetate 
• 107164-86-3 {(S)-3-[(S)-2-(4-Methoxy-benzyloxycarbonylamino)-propionylamino]-2,5-dioxo-pyrrolidin-1-yl}-acetic acid benzyl ester 
• 75007-24-8 H-Glu-Asp-Gly-OH 

Relevant academic research and scientific papers

Dipeptides as leaving group in the enzyme-catalyzed DNA synthesis

Conjugates of 2′-deoxyadenosine monophosphate with dipeptides have been synthesized and tested as substrates for several polymerases. Although the incorporation efficiency is not very high, it demonstrates that some of these dipeptides can be accommodated in the active site of polymerases and function as leaving groups in the enzymatic synthesis of DNA. Copyright

The synthesis and immunosuppressive activities of steroid-urotoxin linkers

The urotoxins (Glu-Asp-Gly-OH, His-Gly-Glu-OH, His-Gly-Lys-OH, and His-Gly-Lys-NHNH2) were introduced into the convenient sites of hydrocortisone and prednisolone via the amidation or condensation reactions to form the corresponding linkers 7a-d, 8a-d, 9a,b, and 10a,b in acceptable yields. The bioassays such as prolongation of heterotopic transplanted cardiac tissue survival in vivo, inhibitory effects on phagocytosis of mouse peritoneal macrophages and concanavalin (ConA) or lipopolysaccharide (LPS) induced proliferation of mouse spleen lymphocytes in vitro show that at the comparable concentrations the immunosuppressive activities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b were higher than that of hydrocortisone, prednisolone, and the urotoxins alone, as well as significantly higher than that of the mixture of hydrocortisone and urotoxins or prednisolone and urotoxins. The so-called 'permissive action' may be responsible for the enhancement of the mentioned bioactivities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b.