75007-24-8

Usage

InChI:InChI=1/C11H17N3O8/c12-5(1-2-7(15)16)10(21)14-6(3-8(17)18)11(22)13-4-9(19)20/h5-6H,1-4,12H2,(H,13,22)(H,14,21)(H,15,16)(H,17,18)(H,19,20)/t5-,6-/m0/s1

Upstream product

• 101559-55-1 N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester 
• 32886-40-1 (S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-(2,5-dioxo-pyrrolidin-1-yl) ester 
• 13574-13-5 Boc-Glu(OBzl)-OH 
• 5680-86-4 N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid 
• 68802-35-7 benzyl (3S)-4-{[2-(benzyloxy)-2-oxoethyl]amino}-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoate 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOSITION COMPRISING THE PEPTIDE GLU-ASP-GLY AND USE FOR TREATING HELICOBACTER PYLORI INDUCED GASTRODUODENAL DISEASES

The invention relates to medicinal means on the basis of a peptide pharmaceutical composition for treatment of Helicobacter pylori-induced gastroduodenal diseases. The technical result of the invention consists in the peptide glutamyl-aspartyl-glycine wit

The synthesis and immunosuppressive activities of steroid-urotoxin linkers

The urotoxins (Glu-Asp-Gly-OH, His-Gly-Glu-OH, His-Gly-Lys-OH, and His-Gly-Lys-NHNH2) were introduced into the convenient sites of hydrocortisone and prednisolone via the amidation or condensation reactions to form the corresponding linkers 7a-d, 8a-d, 9a,b, and 10a,b in acceptable yields. The bioassays such as prolongation of heterotopic transplanted cardiac tissue survival in vivo, inhibitory effects on phagocytosis of mouse peritoneal macrophages and concanavalin (ConA) or lipopolysaccharide (LPS) induced proliferation of mouse spleen lymphocytes in vitro show that at the comparable concentrations the immunosuppressive activities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b were higher than that of hydrocortisone, prednisolone, and the urotoxins alone, as well as significantly higher than that of the mixture of hydrocortisone and urotoxins or prednisolone and urotoxins. The so-called 'permissive action' may be responsible for the enhancement of the mentioned bioactivities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b.