68819-90-9

Upstream product

• 70823-04-0 4-tert-butyl-2,6-dimethylbenzene-1-sulfonyl chloride 
• 98-19-1 5-tert-Butyl-m-xylene 
• 400656-18-0 (4-(tert-butyl)-2,6-dimethylphenyl)magnesium bromide 

Downstream Products

• 1207989-40-9 2-fluoroethyl 4-tert-butyl-2,6-dimethylbenzenesulfinate 
• 1207990-03-1 3-fluoropropyl 4-tert-butyl-2,6-dimethylbenzenesulfinate 
• 1259294-04-6 4-fluorobutyl 4-tert-butyl-2,6-dimethylbenzenesulfinate 
• 1259294-07-9 5-fluoropentyl 4-tert-butyl-2,6-dimethylbenzenesulfinate 
• 1207989-71-6 2-fluoro-2-phenylethyl 4-tert-butyl-2,6-dimethylbenzenesulfinate 
• 1207990-05-3 4-fluoro-2-[4-tert-butyl-2,6-dimethylbenzenesulfinyloxy]pentane 
• 1207990-88-2 4-tert-butyl-2,6-dimethylbenzenesulfinyl fluoride 
• 1207990-56-4 1-(4-tert-butyl-2,6-dimethylphenylsulfinyl)-3-fluoropyrrolidine 
• 1259293-90-7 N-(2-fluoroethyl)-N-methyl-4-tert-butyl-2,6-dimethylbenzensulfinamide 
• 1207990-50-8 N-(2-fluoroethyl)-N-benzyl-4-tert-butyl-2,6-dimethylbenzensulfinamide 
• 1259294-12-6 N-(4-tert-butyl-2,6-dimethylphenylsulfinyl)-3-fluoropiperidine 
• 1207991-16-9 N-(4-tert-butyl-2,6-dimethylphenylsulfonyl)-3-fluoropyrrolidine 
• 1207991-05-6 2-fluoroethyl 4-tert-butyl-2,6-dimethylbenzenesulfonate 
• 68819-92-1 C₂₆H₃₂N₂O₄S₃ 

Relevant academic research and scientific papers

Preparation method for symmetric diaryl disulfide

The invention discloses a preparation method for symmetric diaryl disulfide. The preparation method comprises the following steps: using aromatic hydrocarbon as shown in a general formula (I) as a rawmaterial and reacting with chlorosulfonic acid to generate aryl chlorosulfonic acid, and reacting with sulfoxide chloride to synthesize aryl sulfonyl chloride as shown in a general formula (II); andpreparing the symmetric diaryl disulfide as shown in a general formula (III) under the action of a reducing agent through a reduction reaction by the aryl sulfonyl chloride as shown in the general formula (II). The disclosed preparation method for the symmetric diaryl disulfide has many advantages of low toxicity of the reaction raw material, short reaction time, cheap reagents and easy acquisition, convenient separation and purification and the like, and has very high application value and industrial production value.

Methods for Preparing Diaryl Disulfides

New and useful methods for preparing bulky diaryl disulfides from a benzene derivative and sulfur halide are disclosed.

Discovery of 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride as a deoxofluorinating agent with high thermal stability as well as unusual resistance to aqueous hydrolysis, and its diverse fluorination capabilities including deoxofluoro-arylsulfinylation with high stereoselectivity

Versatile, safe, shelf-stable, and easy-to-handle fluorinating agents are strongly desired in both academic and industrial arenas, since fluorinated compounds have attracted considerable interest in many areas, such as drug discovery, due to the unique effects of fluorine atoms when incorporated into molecules. This article describes the synthesis, properties, and reactivity of many substituted and thermally stable phenylsulfur trifluorides, in particular, 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (Fluolead, 1k), as a crystalline solid having surprisingly high stability on contact with water and superior utility as a deoxofluorinating agent compared to current reagents, such as DAST and its analogues. The roles of substiuents on 1k in thermal and hydrolytic stability, fluorination reactivity, and the high-yield fluorination mechanism it undergoes have been clarified. In addition to fluorinations of alcohols, aldehydes, and enolizable ketones, 1k smoothly converts non-enolizable carbonyls to CF2 groups, and carboxylic groups to CF3 groups, in high yields. 1k also converts C(=S) and CH3SC(=S)O groups to CF2 and CF3O groups, respectively, in high yields. In addition, 1k effects highly stereoselective deoxofluoro-arylsulfinylation of diols and amino alcohols to give fluoroalkyl arylsulfinates and arylsulfinamides, with complete inversion of configuration at fluorine and the simultaneous, selective formation of one conformational isomer at the sulfoxide sulfur atom. Considering the unique and diverse properties, relative safety, and ease of handling of 1k in addition to its convenient synthesis, it is expected to find considerable use as a novel fluorinating agent in both academic and industrial arenas.

SUBSTITUTED PHENYLSULFUR TRIFLUORIDE AND OTHER LIKE FLUORINATING AGENTS

Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds.

Substituted phenylsulfur trifluoride and other like fluorinating agents

Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds.