68826-68-6Relevant academic research and scientific papers
Pyrrolidine Analogues of 2',3'-Dideoxynucleosides: Synthesis via 9-Aminopurines and 1-Aminopyrimidines
Harnden, Michael R.,Jarvest, Richard L.
, p. 2073 - 2080 (2007/10/02)
Analogues of 2',3'-dideoxynucleosides in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an N-N bond have been prepared.The adenine 26, guanine 25 and and hypoxanthine 27 compounds were synthesised via 9-aminopurines.Corresponding derivatives of 5-iodouracil 31, 5-chlorouracil 33 and 5-chlorocytosine 35 were prepared by substitution at the 5-position of hydroxy protected uracil derivatives.Enantiomers, 40a and 40b, of the pyrrolidine analogue of dideoxycytidine were prepared from 1-aminocytosine.The novel N-aminobases 9-aminoadenine 10, 1-aminocytosine 13 and 1-aminothymine 15 are described.
