68827-43-0

Usage

Uses

Used in Pharmaceutical Industry:
Benzenecarboximidamide, 3,4-diaminois utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, Benzenecarboximidamide, 3,4-diaminois employed as a precursor in the production of dyes. Its chemical properties enable it to be transformed into a range of colored compounds, which are then used in various applications such as textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
As a versatile building block in organic chemistry, Benzenecarboximidamide, 3,4-diaminois used as a reagent in various chemical reactions. It serves as a starting material for the synthesis of complex organic molecules, facilitating the exploration of new chemical pathways and the development of innovative compounds.
Used in Industrial Product Manufacturing:
Benzenecarboximidamide, 3,4-diaminois also employed in the manufacturing of various industrial products. Its diverse applications include the production of specialty chemicals, agrochemicals, and other consumer goods, where it contributes to the development of new materials and technologies.

InChI:InChI=1/C7H10N4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,8-9H2,(H3,10,11)

Upstream product

• 1144100-39-9 C₉H₁₃N₃O*ClH 
• 29289-18-7 N-(4-cyano-2-nitrophenyl)acetamide 
• 6393-40-4 4-Amino 3-nitro-benzonitrile 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 873-74-5 4-Aminobenzonitrile 
• 777833-25-7 4-Amino-3-nitro-benzimidic acid methyl ester 
• 148344-28-9 4-amino-3-nitrobenzamidine 

Downstream Products

• 742676-79-5 N-[4-(5-Carbamimidoyl-1H-benzoimidazol-2-yl)-2-nitro-phenyl]-acetamide 
• 878674-44-3 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6-(2-methoxy-ethoxymethoxy)-3'-nitro-biphenyl-3-yl]-succinic acid dimethyl ester 
• 878674-71-6 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-fluoro-2'-methoxy-6-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-succinic acid dimethyl ester 
• 1451058-75-5 2-[5⁽⁶⁾-amidino-2-benzimidazoyl]-5-(4-nitrophenyl)furan monohydrochloride 
• 871266-67-0 dibenzyl (S)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinate 

Relevant academic research and scientific papers

Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents

A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more act

Sulfonamide bridging compounds that inhibit tryptase activity

The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.

Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles)

A series of bis(amidinobenzimidazoles) and bis(amidinoindoles) with varied linking chains connecting the aromatic groups and various modifications to the basic amidino groups have been prepared. The calf thymus (CT) DNA and nucleic acid homopolymer [poly(dA)·poly(dT), poly(dA-dT)·poly-(dA-dT), and poly(dG-dC)·poly(dG-dC)] binding properties of these compounds have been studied by thermal denaturation (ΔT(m)) and viscosity. The compounds show a greater affinity for poly(dA)·poly(dT) and poly(dA-dT)·poly(dA-dT) than for poly(dG-dC)·poly(dG-dC). Viscometric titrations indicate that the compounds do not bind by intercalation. Molecular modeling studies and the biophysical data suggest that the molecules bind to the minor groove of CT DNA and homopolymers. Analysis of the shape of the molecules is consistent with this mode of nucleic acid binding. Compounds with an even number of methylenes connecting the benzimidazole rings have a higher affinity for DNA than those with an odd number of methylenes. Molecular modeling calculations that determine the radius of curvature of four defined groups in the molecule show that the shape of the molecule, as a function of chain length, affects the strength of nucleic acid binding. Electronic effects from cationic substituents as well as hydrogen bonding from the imidazole nitrogens also contribute to the nucleic acid affinity. The bis(amidinoindoles) show no structurally associated differential in nucleic acid base pair specificity or affinity.