688363-79-3

Basic information

• Product Name: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-
• CAS NO: 688363-79-3
• Molecular Formula: C13H10BrNO3
• Molecular Weight: 308.131
• Mol File: 688363-79-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(688363-79-3)
• EPA Substance Registry System: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(688363-79-3)

Safety Data

• Hazardous Substances Data: 688363-79-3(Hazardous Substances Data)

Usage

General Description

Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-, also known as 1-Bromo-3-nitro-2-anisylbenzene, is an organic compound with the molecular formula C13H10BrNO4. It is a colorless to pale yellow liquid commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is also used in the production of dyes and other organic compounds. It is important to handle this compound with care and follow safety precautions, as it is toxic and may cause irritation to the skin, eyes, and respiratory system. Proper handling, storage, and disposal procedures should be followed to avoid any potential harm.

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 688363-78-2 4-(2-benzyloxy-3-nitro-phenyl)-piperazine-1-carboxylic Acid Tert-butyl Ester 
• 1097777-69-9 ethyl 3-({3-nitro-2-[(phenylmethyl)oxy]phenyl}amino)benzoate 
• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 
• 1916-59-2 2-aminophenoxazin-3-one 
• 376591-97-8 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride 
• 1097777-70-2 ethyl 3-[(3-amino-2-hydroxyphenyl)amino]benzoate 

Relevant articles and documents

Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl) -1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

G-protein-coupled receptor kinase (GRK)-2 and -5 are emerging therapeutic targets for the treatment of cardiovascular disease. In our efforts to discover novel small molecules to inhibit GRK-2 and -5, a class of compound based on 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine was identified as a novel hit by high throughput screening campaign. Structural modification of parent benzoxazole scaffolds by introducing substituents on phenyl displayed potent inhibitory activities toward GRK-2 and -5.

JAK INHIBITORS

Disclosed is a series of JAK inhibitors, which specifically relates to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.

Process for the preparation of a thrombopoietin agonist

The present invention relates to a process for the preparation of a thrombopoietin agonist, intermediates useful in its preparation, and a process for the preparation of said intermediates.