68838-94-8 Usage
Uses
Used in Pharmaceutical and Research Applications:
D-Leucine, phenylmethyl ester, hydrochloride is utilized as an intermediate in the synthesis of various compounds, playing a crucial role in the development of pharmaceuticals and research chemicals. Its enhanced stability and solubility, attributed to the phenylmethyl ester group, make it suitable for a wide range of applications in these fields.
Used in Peptide and Protein Synthesis:
In the field of biochemistry, D-Leucine, phenylmethyl ester, hydrochloride serves as a key building block for the synthesis of peptides and proteins. Its properties allow for the creation of complex biologically active molecules that can be used for therapeutic or research purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 68838-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,8,3 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68838-94:
(7*6)+(6*8)+(5*8)+(4*3)+(3*8)+(2*9)+(1*4)=188
188 % 10 = 8
So 68838-94-8 is a valid CAS Registry Number.
68838-94-8Relevant academic research and scientific papers
Design and synthesis of peptides passing through the blood-brain barrier
Wakamiya, Tateaki,Kamata, Makoto,Kusumoto, Shoichi,Kobayashi, Hiroyuki,Sai, Yoshimichi,Tamai, Ikumi,Tsuji, Akira
, p. 699 - 709 (2007/10/03)
The blood-brain barrier (BBB) is a highly selective membranous barrier regulating the transport of substances in blood into the brain parenchyma. At present, delivery of biologically active peptides or peptide drugs into the brain is quite an important subject from the standpoint of chemotherapy for brain diseases H-MeTyr-Arg-MeArg-D-Leu-NH(CH2)8NH2 termed 001-C8 was first synthesized to elucidate the structural specificity of peptides for passing through the BBB. The Na-methylamino acid and D-amino acid residues were appropriately situated in this peptide to protect against the digestion by peptidase. Furthermore, a number of basic peptides were prepared as 001-C8 analogs for studying the relationship between structure and BBB permeability of peptides.
