68870-52-0

Upstream product

• 141-97-9 ethyl acetoacetate 
• 622-37-7 Phenyl azide 
• 62-53-3 aniline 
• 4916-22-7 methyl 3-phenylaminobut-2-enoate 
• 623-43-8 methyl crotonate 
• 67-56-1 methanol 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1392400-54-2 dimethyl 5,5'-((1E,3Z)-4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(1-phenyl)-1H-1,2,3-triazole-4-carboxylate 
• 1392400-51-9 methyl 5-[(E)-2-(dimethylamino)ethenyl]-1-phenyl-1H-1,2,3-triazole-4-carboxylate 
• 117693-99-9 4-Methoxycasrbonyl-1-phenyl-1,2,3-triazole-5-carbaldehyde p-tosylhydrazone 
• 117693-94-4 5-Azidomethyl-4-methoxycarbonyl-1-phenyl-1,2,3-triazole 
• 117694-02-7 5-Diazomethyl-4-methoxycarbonyl-1-phenyl-1,2,3-triazole 
• 117693-97-7 5-Formyl-4-methoxycarbonyl-1-phenyl-1,2,3-triazole 

Relevant academic research and scientific papers

Organocatalytic Enamine–Azide Addition Reaction in the Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles

Abstract: A high efficiency of diethanolamine as organocatalyst in the cycloaddition of organic (including heterocyclic) mono-, di-, and triazides to active methylene compounds has been demonstrated. As a result, a number of functionally substituted bi- a

Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) is an active catalyst in C?H-amination but also in proton-transfer catalysis. Herein, we describe the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides and ketones to the corresponding 1,2,3-triazoles. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C?H amination product. An example of a successful sequential Dimroth triazole–indoline synthesis to the corresponding triazole-substituted indolines is presented.

A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions

An acetic acid-promoted approach that enables the synthesis of 1,4,5-trisubstituted 1,2,3-triazole derivatives has been achieved. This transformation employs readily available primary amines, 1,3-dicarbonyls and tosyl azide as the starting materials via a

Cycloadduct formation of α,β-unsaturated esters with azides catalyzed by NHC systems

NHC-catalyzed cycloadduct formation of α,β-unsaturated esters with azides has been developed. This strategy could generate 1,2,3-triazoles and dihydropyrazoles with high yields and regioselectivities in the presence of an N-heterocyclic carbene catalyst.

SYNTHESIS AND THERMAL REARRANGEMENT OF 5-DIAZOMETHYL-1,2,3-TRIAZOLES

5-Diazomethyl-4-methoxycarbonyltriazoles are capable of undergoing ring-degenerate rearrangements (19+20) when a strong electron withdrawing substituent (e.g. p-nitrophenyl or o,p-dinitrophenyl) is located at the N-1 position.Whereas the unrearranged diaz