688782-45-8Relevant articles and documents
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production
Kolman, Viktor,Kal?ic, Filip,Jansa, Petr,Zídek, Zdeněk,Janeba, Zlatko
, p. 295 - 301 (2018/07/14)
As a part of a broader structure-activity relationship study of substituted 2-aminopyrimidines, the influence of the C-5 substitution on inhibition of prostaglandin E2 (PGE2) production was studied. Thirty compounds were prepared sta
Potent and selective adenosine A2A receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones
Harris, Joel M.,Neustadt, Bernard R.,Zhang, Hongtao,Lachowicz, Jean,Cohen-Williams, Mary,Varty, Geoff,Hao, Jinsong,Stamford, Andrew W.
scheme or table, p. 2497 - 2501 (2011/05/15)
Antagonism of the adenosine A2A receptor affords a possible treatment of Parkinson's disease. In the course of investigating pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonists, we prepared [1,2,4]-triazolo[4,3-c]pyrimidi
PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS
-
Page/Page column 55, (2008/06/13)
Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G', and G" represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.