68901-09-7

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-5-(methylsulphamoyl)benzoic acid is used as an intermediate in the synthesis of pharmaceuticals for its potential antimicrobial and anti-inflammatory properties.
Used in Agrochemical Industry:
2-chloro-5-(methylsulphamoyl)benzoic acid is used as an intermediate in the synthesis of agrochemicals to develop new compounds for pest control and crop protection.
Used in Enzyme Inhibition:
2-chloro-5-(methylsulphamoyl)benzoic acid is used as an inhibitor of the enzyme carbonic anhydrase, which has shown promising results in the treatment of certain diseases such as glaucoma and epilepsy.

InChI:InChI=1/C8H8ClNO4S/c1-10-15(13,14)5-2-3-7(9)6(4-5)8(11)12/h2-4,10H,1H3,(H,11,12)/p-1

Upstream product

• 89692-75-1 2-Chloro-5-sulfino-benzoic acid 
• 74-89-5 methylamine 
• 21346-66-7 2-chloro-5-(fluorosulfonyl)benzoic acid 
• 137-64-4 2-chloro-5-(chlorosulfonyl)benzoic acid 

Downstream Products

• 29636-27-9 2-amino-5-(methylsulfamoyl)benzoic acid 
• 909418-62-8 methyl 2-chloro-5-[(methylamino)sulfonyl]benzoate 
• 847545-68-0 3-[4-(4-acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N-methyl-benzenesulfonamide 
• 90438-27-0 methyl 2-amino-5-(methylsulfamoyl)benzoate 

Relevant academic research and scientific papers

ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Sulfanyl substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.

1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES

A compound of formula (I) wherein the substituents are described in claim 1 for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).