68905-99-7

Basic information

• Product Name: 4(1H)-Pyrimidinone, 6-hydroxy-5-nitro-2-phenyl-
• Synonyms: 5-NITRO-2-PHENYL-4,6-PYRIMIDINEDIOL
• CAS NO: 68905-99-7
• Molecular Formula: C₁₀H₇N₃O₄
• Molecular Weight: 233.18
• Mol File: 68905-99-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 6-hydroxy-5-nitro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 6-hydroxy-5-nitro-2-phenyl-(68905-99-7)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 6-hydroxy-5-nitro-2-phenyl-(68905-99-7)

Safety Data

• Hazardous Substances Data: 68905-99-7(Hazardous Substances Data)

Upstream product

• 13566-71-7 2-Phenyl-4,6-dihydroxy-pyrimidine 
• 17424-17-8 6-phenyl-pyridine-2,4-diol 
• 1670-14-0 benzamidine monohydrochloride 

Downstream Products

• 68921-91-5 2-Phenyl-5-nitro-4,6-dichloro-pyrimidine 
• 192631-85-9 5-Nitro-N,N'-dipentyl-2-phenyl-pyrimidine-4,6-diamine 
• 192631-80-4 N-Benzyl-N'-butyl-5-nitro-2-phenyl-pyrimidine-4,6-diamine 
• 192631-77-9 N,N'-Dibenzyl-5-nitro-2-phenyl-pyrimidine-4,6-diamine 
• 192631-78-0 N-Benzyl-N'-cyclopentyl-5-nitro-2-phenyl-pyrimidine-4,6-diamine 
• 192631-81-5 N-Benzyl-5-nitro-N'-pentyl-2-phenyl-pyrimidine-4,6-diamine 
• 192631-83-7 N,N'-Dicyclohexyl-5-nitro-2-phenyl-pyrimidine-4,6-diamine 
• 192631-79-1 N-Benzyl-N'-cyclohexyl-5-nitro-2-phenyl-pyrimidine-4,6-diamine 
• 1415583-54-8 C₂₂H₃₃N₇O₂ 
• 1415583-53-7 C₂₂H₃₁N₇O₄ 
• 1415583-40-2 C₂₃H₃₁N₇O₃ 
• 1415583-43-5 C₂₃H₃₁N₇O₂ 

Relevant articles and documents

NOVEL IMMUNE SYSTEM MODULATORS

The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

2-aryl-8-oxodihydropurine derivative, process for the producing the same, medicinal compositions containing the same, and intermediates thereof

2-Aryl-8-oxodihydropurine derivative of the following formula (I): wherein W is H, lower alkyl, halogen, lower alkoxy, amino, mono- or di-lower alkylamino, or substituted or unsubstituted phenyl; X is H, lower alkyl, cycloalkyl-lower alkyl, substituted or unsubstituted phenyl-lower alkyl, lower alkenyl, carbamoyl, di-lower alkylcarbamoyl, or a group of the formula (Q): —CH(R3)CON(R1)(R2); Y is H, lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, lower alkenyl, substituted or unsubstituted phenyl-lower alkyl, or a group of the formula (Q): —CH(R3)CON(R1)(R2); A is substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; provided that when one of X and Y of the above formula (I) is the group of the formula (Q), then the other is the same groups for X or Y as described above except for the group of the formula (Q), or a pharmaceutically acceptable acid addition salt thereof. These compounds are useful for the prophylaxis or treatment of central nervous disorders such as anxiety-related diseases (neurosis, somatoform disorders, anxiety disorders, and others), depression, epilepsy, etc., or circulatory organs disorders such as angina pectoris, hypertension.

Synthesis of 4,6-disubstituted- and 4,5,6-trisubstituted-2-phenyl- pyrimidines and their affinity towards A1 adenosine receptors

Synthesis and assay of title compounds are reported. The results can support our hypothesis about the possibility that molecules characterized by great flexibility, as the title 2-phenyl-4,5,6-triaminopyrimidines, can better interact with the receptor sites compared with rigid molecules as 2,6,9-trisubstituted 8-azaadenines. Relatively low activity shown by pyrimidine derivatives demonstrated the importance of the bicyclic aromatic system in 8-azaadenines and adenines to give a favourable interaction between a hexogenous molecule and the A1 adenosine receptors.

CERTAIN ARYL FUSED PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The present invention encompasses structures of the formula: STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein: STR2 and X represents hydrogen, halogen, or hydroxy; W represents an aryl group unsubstituted or substituted with

CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS

The invention encompasses a compound of the formula STR1 and the pharmaceutically acceptable non-toxic salts thereof wherein X, W, Y, R, and R2 are variables.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.

2-aryl-4,6-dihalopyrimidines as antidote for protecting cultivated plants from phytotoxic damage caused by herbicides

2-Aryl-4,6-dihalopyrimidines of the formula I STR1 wherein Hal is halogen, E is unsubstituted or substituted phenyl, thienyl or furyl, and Y is a group bound by way of nitrogen, oxygen or sulfur, are able as antidote or `safener` to protect cultivated plants against the phytotoxic action of herbicides. Cultivated plants concerned are particularly sorghum, cereals, maize, rice and soya bean, and herbicides concerned are chloroacetanilides or other herbicidally effective substances.