192631-77-9Relevant academic research and scientific papers
Synthesis of 4,6-disubstituted- and 4,5,6-trisubstituted-2-phenyl- pyrimidines and their affinity towards A1 adenosine receptors
Biagi,Giorgi,Livi,Scartoni,Lucacchini
, p. 61 - 65 (2007/10/03)
Synthesis and assay of title compounds are reported. The results can support our hypothesis about the possibility that molecules characterized by great flexibility, as the title 2-phenyl-4,5,6-triaminopyrimidines, can better interact with the receptor sites compared with rigid molecules as 2,6,9-trisubstituted 8-azaadenines. Relatively low activity shown by pyrimidine derivatives demonstrated the importance of the bicyclic aromatic system in 8-azaadenines and adenines to give a favourable interaction between a hexogenous molecule and the A1 adenosine receptors.
