689248-39-3Relevant academic research and scientific papers
6-Methyl δ-lactol derived chiral glycine equivalents for the asymmetric synthesis of protected α-amino amides
Dixon, Darren J.,Horan, Richard A. J.,Monck, Nathaniel J. T.
, p. 913 - 916 (2007/10/03)
Two new δ-lactol derived chiral glycine equivalents have been prepared in one-pot processes in good yields from the known 6- methyltetrahydropyran-2-ol. Alkylation proceeds in moderate to good yields and moderate to good selectivities under experimentally simple conditions. The lactol chiral auxiliary is readily removed under mild acidic conditions to give N-Cbz protected alpha-amino amides in good yields.
