689250-53-1

Basic information

• Product Name: 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)
• Synonyms: 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)
• CAS NO: 689250-53-1
• Molecular Formula: C₁₁H₉FN₂O
• Molecular Weight: 204.2003632
• Mol File: 689250-53-1.mol

Chemical Properties

• Boiling Point: 353.1°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 3.66E-05mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)(689250-53-1)
• EPA Substance Registry System: 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE)(689250-53-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 689250-53-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9FN2O/c1-14-6-9(7-15)11(13-14)8-2-4-10(12)5-3-8/h2-7H,1H3

Upstream product

• 306936-57-2 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde 
• 74-88-4 methyl iodide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 326-33-0 4-fluoroacetophenone semicarbazone 
• 689250-51-9 C₁₁H₁₁FN₂O 
• 1176628-01-5 C₁₁H₁₁FN₂O 

Relevant articles and documents

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.

AGENT FOR PREVENTING OR TREATING NEUROPATHY

The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula:wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s);B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group;X is a divalent acyclic hydrocarbon group;Z is -O-, -S-, -NR2-, -CONR2- or -NR2CO- (R2 is a hydrogen atom or an optionally substituted alkyl group);Y is a bond or a divalent acyclic hydrocarbon group;R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be -O-, or a salt thereof.