689260-01-3Relevant academic research and scientific papers
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents
Xiao, Zhiyan,Han, Shiqing,Bastow, Kenneth F.,Lee, Kuo-Hsiung
, p. 1581 - 1584 (2004)
An 11,13-O,O′-cyclosulfite GL-331 analogue (7) was synthesized in six steps from podophyllotoxin and evaluated as a potential antitumor agent. Compound 7 was significantly cytotoxic against human tumor cell lines, but showed no inhibition against human DN
Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin
Zhang, Zhi-Jun,Tian, Jing,Wang, Li-Ting,Wang, Mei-Juan,Nan, Xiang,Yang, Liu,Liu, Ying-Qian,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung
, p. 204 - 210 (2014/01/17)
Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC50: 1.41-1.76 μM) and 14e (IC5
