68962-14-1

Basic information

• Product Name: 1,2,3,4-Tetrahydro-5-methoxycarbazole
• Synonyms: 1,2,3,4-Tetrahydro-5-methoxycarbazole;2,3,4,9-Tetrahydro-5-Methoxy-1H-carbazole
• CAS NO: 68962-14-1
• Molecular Formula: C13H15NO
• Molecular Weight: 201.2643
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 68962-14-1.mol

Chemical Properties

• Melting Point: 126-127 °C
• Boiling Point: 364.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• PKA: 18.07±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-5-methoxycarbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-5-methoxycarbazole(68962-14-1)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-5-methoxycarbazole(68962-14-1)

Safety Data

• Hazardous Substances Data: 68962-14-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-5-methoxycarbazole is used as a key intermediate in the synthesis of C-15 Vindoline analogues, which are important compounds with potential applications in the development of new drugs. These analogues have been studied for their ability to act as potassium channel blockers, which can be utilized in ophthalmic compositions for the treatment of ocular hypertension.
Additionally, 1,2,3,4-Tetrahydro-5-methoxycarbazole may also find use in other areas of the pharmaceutical industry, such as the development of novel therapeutic agents targeting various diseases and conditions, due to its unique chemical structure and potential biological activities. Further research and development efforts are needed to fully explore and exploit the potential of this carbazole derivative in the field of drug discovery and development.

Upstream product

• 108-94-1 cyclohexanone 
• 39232-91-2 m-methoxyphenylhydrazine hydrochloride 
• 380383-81-3 tert-butyl 1-(3-methoxyphenyl)hydrazinecarboxylate 
• 68962-18-5 cyclohexanone-(3-methoxy-phenylhydrazone) 
• 93830-99-0 1,2,3,4,4a,9a-hexahydro-5-methoxycarbazole 
• 15384-39-1 (3-methoxyphenyl)hydrazine 
• 855710-53-1 8-chloro-5-methoxy-1,2,3,4-tetrahydro-carbazole 

Relevant articles and documents

OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION

This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

Synthesis of C-15 vindoline analogues by palladium-catalyzed cross-coupling reactions

(Chemical Equation Presented) Described are general protocols for the rapid construction of various C-15-substituted analogues of vindoline using palladium-catalyzed cross-coupling reactions. The required bromo-and iodovindolines were prepared in high yie

Mechanism of Fischer Reaction. Dependence of Thermal Indolization of Cyclohexanone Arylhydrazones on Nature of Substituent in the Benzene Ring

The kinetics of the Fischer thermal indolization of monosubstituted cyclohexanone arylhydrazones was studied by the spectrophotometric method.The enthalpy and entropy of activation of the reaction were calculated.The data obtained were interpreted in terms of a consistent mechanism of formation of a carbon-carbon bond (the -sigmatropic shift).It was found that the influence of the electronic factors on the rate of the sigmatropic rearrangement is inappreciable.

Dehydrogenation of Indolines to Indoles via Azasulphonium Salts or N-Chloramines

The dehydrogenation of indolines to indoles without using mineral oxidising reagents is described.The conversion was achieved via either azasulphonium salts or N-chloramines, the former route involving milder conditions but a more complex procedure.