15384-39-1

Basic information

• Product Name: (3-Methoxy-phenyl)-hydrazine
• Synonyms: (3-Methoxy-phenyl)-hydrazine;m-Methoxyphenylhydrazine;Hydrazine, (3-methoxyphenyl)-
• CAS NO: 15384-39-1
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• Product Categories: Benzene series
• Mol File: 15384-39-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 59-60 °C
• Boiling Point: 275℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.150
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.41±0.10(Predicted)
• CAS DataBase Reference: (3-Methoxy-phenyl)-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Methoxy-phenyl)-hydrazine(15384-39-1)
• EPA Substance Registry System: (3-Methoxy-phenyl)-hydrazine(15384-39-1)

Safety Data

• Hazardous Substances Data: 15384-39-1(Hazardous Substances Data)

Usage

General Description

(3-Methoxy-phenyl)-hydrazine is a chemical compound with the formula C7H10N2O. It is a colorless to yellow liquid with a slight amine odor, and is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate for the preparation of dyes and pigments. (3-Methoxy-phenyl)-hydrazine is known to be an irritant to the skin, eyes, and respiratory system, and may be harmful if swallowed or inhaled. Proper safety measures should be taken when handling and using this chemical.

Upstream product

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Downstream Products

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• 57638-63-8 2-(3-methoxyphenyl)-1H-indole 

Relevant articles and documents

Synthesis and antiinflammatory activity of 2,3-bis(p-methoxyphenyl)indole and related compounds.

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Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid

N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.

Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl) ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3- triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.