68963-18-8

Usage

InChI:InChI=1/C9H12O4/c1-7(6-13-9(3)11)4-5-12-8(2)10/h4-6H,1-3H3

Upstream product

• 108-05-4 vinyl acetate 
• 108-24-7 acetic anhydride 

Downstream Products

• 56269-66-0 2-methyl-4,4-diacetoxy-but-2-enal 
• 88543-52-6 (Z)-2-Methyl-2,4-diacetoxy-but-3-enal 
• 88543-51-5 2-methyl-2,4-diacetoxy-but-3-enal 
• 101513-14-8 Acetic acid (Z)-1-acetoxy-3-methyl-4-oxo-but-2-enyl ester 
• 112549-36-7 Acetic acid (E)-1-acetoxy-2-methyl-4-oxo-but-2-enyl ester 

Relevant academic research and scientific papers

Caulerpenyne and related bis-enol esters are novel-type inhibitors of human 5-lipoxygenase

Caulerpenyne (CYN) is a sesquiterpene from green algae with known inhibitory properties against soybean lipoxygenase. Here we introduce a detailed structure-activity study elucidating the inhibitory effects of CYN and a library of six synthetic CYN analogues on isolated human 5-lipoxygenase (5-LO) and cellular 5-LO in polymorphonuclear leukocytes. Essential structural elements are identified and a structurally simplified inhibitor is introduced. The modes of 5-LO inhibition by CYN and the synthetic inhibitors cannot be assigned to any of the known categories of lipoxygenase inhibitors. These compounds clearly interfere directly with 5-LO and represent rather small and flexible molecules, with unique structures among 5-LO inhibitors identified thus far.