69008-70-4

Basic information

• Product Name: N,N-Dipropylpyridin-4-AMine
• Synonyms: N,N-Dipropylpyridin-4-AMine
• CAS NO: 69008-70-4
• Molecular Formula: C11H18N2
• Molecular Weight: 178.27402
• Mol File: 69008-70-4.mol

Chemical Properties

• Boiling Point: 270.2°C at 760 mmHg
• Flash Point: 117.2°C
• Appearance: /
• Density: 0.954g/cm³
• Vapor Pressure: 0.00695mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: N,N-Dipropylpyridin-4-AMine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dipropylpyridin-4-AMine(69008-70-4)
• EPA Substance Registry System: N,N-Dipropylpyridin-4-AMine(69008-70-4)

Safety Data

• Hazardous Substances Data: 69008-70-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N,N-Dipropylpyridin-4-AMine is used as a reactant in organic synthesis for the development of various pharmaceutical drugs and agrochemicals. Its unique structure and properties make it a valuable building block in the creation of new compounds with therapeutic and agricultural benefits.
Used in Cardiovascular and Inflammatory Disease Treatments:
N,N-Dipropylpyridin-4-AMine is used as a potential therapeutic agent for cardiovascular and inflammatory diseases due to its anti-inflammatory and anti-thrombotic properties. Its ability to modulate key biological pathways involved in these conditions positions it as a promising candidate for the development of new medications.
Used in Industrial Applications:
N,N-Dipropylpyridin-4-AMine is also investigated for its potential as a corrosion inhibitor in industrial settings. Its capacity to protect materials from corrosion could enhance the durability and longevity of various industrial components, contributing to cost savings and improved efficiency in manufacturing processes.

InChI:InChI=1/C11H18N2/c1-3-9-13(10-4-2)11-5-7-12-8-6-11/h5-8H,3-4,9-10H2,1-2H3

Upstream product

• 1013629-48-5 3-bromo-4-(N,N-diallylamino)pyridine 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 142-84-7 di-n-propylamine 
• 626-55-1 3-Bromopyridine 

Relevant articles and documents

Method of synthesizing 4-alkylamino pyridine in mild condition

The invention discloses a method of synthesizing 4-alkylamino pyridine in a mild condition, and belongs to the technical field of organic synthesis. The method comprises performing a nucleophilic substitution reaction on 4-chloropyridine hydrochloride with alkyl amine in the presence of an inhibitor to prepare the 4-alkylamino pyridine, wherein the reaction temperature is in a range of 30-150 DEG C, the reaction time is in a range of 1-10 hours, the inhibitor is a fluoride salt, and the mass ratio of the inhibitor to the 4-chloropyridine hydrochloride is (0.1-1):1. In order to solve the problem of production safety hidden danger caused by a sharp rise of temperature in such kind of nucleophilic substitution reactions, the method provided by the invention introduces the inhibitor to control the reaction speed. With the addition of the inhibitor, the rise of the reaction temperature is effectively controlled, the reaction temperature and reaction speed are reduced to a controllable range, and thus the method provides possibility for safe production and is suitable for large-scale production. In addition, the synthetic reaction has only one step, the yield can reach 80%, and compared with the products of nucleophilic substitution reactions with no inhibitors, the product purity is increased and can reach 99% or more.

Inductive effects through Alkyl Groups - How long is long enough?

The influence of the length of alkyl substituents on various kinetic, thermodynamic, and spectroscopic properties of 4-(dialkylamino)pyridines has been determined by using a combination of experimental and theoretical methods. The chain-length dependence of these properties has subsequently been analyzed by using a quantitative model for through-bond inductive effects. Substituent effects of linear alkyl groups show a saturation effect beyond four carbon atoms for numerous properties of 4-(dialkylamino)pyridines as test substrates. These observations can be rationalized by using an increment-based method for the calculation of inductive substituent effects. Copyright

Preparation of the isomeric azaindoline family by intramolecular carbolithiation

An operationally convenient, one-pot, three-step sequence has been developed that provides access to 3-substituted 4-, 5-, 6-, and 7-azaindolines (2,3-dihydro-1H-pyrollopyridines) via intramolecular carbolithiation of the aryllithium derived from an appro

Complex base-induced generation of 3,4-didehydropyridine derivatives: New access to aminopyridines or pyridones

The complex base, NaNH2-tert-BuONa, in THF easily transforms 3-bromopyridine and 2-pyridone derivatives into the corresponding hetarynes. The reaction of representative amines (dialkylamines, morpholine, piperidine) with these reactive intermediates leads to the preparation of aminopyridines in good yields and illustrates the synthetic usefulness of such reactions.