N,N-Dipropylpyridin-4-AMine

Base Information

• Chemical Name: N,N-Dipropylpyridin-4-AMine
• CAS No.: 69008-70-4
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.277
• Hs Code.: 2933399090
• Mol file: 69008-70-4.mol

Synonyms:N,N-Dipropylpyridin-4-AMine

Chemical Property of N,N-Dipropylpyridin-4-AMine

Chemical Property:

• Vapor Pressure: 0.00695mmHg at 25°C
• Boiling Point: 270.2°C at 760 mmHg
• Flash Point: 117.2°C
• PSA: 16.13000
• Density: 0.954g/cm³
• LogP: 2.70800
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dipropylpyridin-4-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dipropylpyridin-4-AMine

There total 4 articles about N,N-Dipropylpyridin-4-AMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

4-chlorpyridine hydrochloride (7379-35-3) + di-n-propylamine (142-84-7) → 4-dipropylaminopyridine (69008-70-4)

Guidance literature:

With potassium fluoride; at 110 ℃; for 8h; Large scale;

Reference yield: 40.0%

3-bromo-4-(N,N-diallylamino)pyridine (1013629-48-5) → 3-methyl-1-propyl-5-azaindoline (1013629-58-7) + 4-dipropylaminopyridine (69008-70-4)

Guidance literature:

3-bromo-4-(N,N-diallylamino)pyridine; With tert.-butyl lithium; In diethyl ether; n-heptane; pentane; at -78 - 0 ℃; for 2.5h; Inert atmosphere;

With methanol; In diethyl ether; n-heptane; pentane;

With 5% Pd/C; hydrogen; In ethanol; for 44h; under 760.051 Torr;

DOI:10.1021/ol702862d

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) + di-n-propylamine (142-84-7) → 4-dipropylaminopyridine (69008-70-4) + N,N-dipropylpyridin-3-amine

Guidance literature:

With sodium amide; tert-butyl alcohol; In tetrahydrofuran; at 20 ℃; for 0.166667h; Yield given. Yields of byproduct given;

upstream raw materials:

3-Bromopyridine

di-n-propylamine

3-bromo-4-(N,N-diallylamino)pyridine

4-chlorpyridine hydrochloride

Refernces

• 1、 Tandon, Raman,Nigst, Tobias A.,Zipse, Hendrik. "Inductive effects through Alkyl Groups - How long is long enough?". supporting information. p. 5423 - 5430. Retrieved 2013/09/02.
• 2、 Vinter-Pasquier, Karine,Jamart-Gregoire, Brigitte,Caubere, Paul. "Complex base-induced generation of 3,4-didehydropyridine derivatives: New access to aminopyridines or pyridones". . p. 2113 - 2129. Retrieved 2007/10/03.