690206-97-4 Usage
Uses
Used in Pharmaceutical Industry:
ZM 306416 is used as an anti-cancer agent for its ability to inhibit the tyrosine kinase RTK signaling pathway, which is involved in tumor growth and metastasis. It acts as an anti-tumor and anti-metastatic agent, making it a valuable compound in the development of cancer treatments.
Used in Metabolite Research:
In the field of metabolite research, ZM 306416 is used as a major metabolite of Meropenem, a carbapenem antibiotic. Its study helps in understanding the metabolic pathways and the behavior of the antibiotic in the body, which can be crucial for optimizing drug dosages and minimizing side effects.
Used in Drug Metabolism and Pharmacokinetics:
ZM 306416 is used as a research tool to investigate the metabolism and pharmacokinetics of Meropenem. Understanding the coexistence of the two isomers (1-pyrroline and 2-pyrroline) at equilibrium in aqueous solutions, as observed by NMR, can provide insights into the drug's absorption, distribution, metabolism, and excretion, ultimately contributing to the optimization of its therapeutic use.
Biological Activity
zm 306416 is a selective inhibitor of vegfr with ic50 value of 0.67μm [1]. it is also reported that zm 306416 inhibits egfr with ic50 value less than 10 nm [2].vascular endothelial growth factor receptor (vegfr) is a key element of the extracellular matrix(ecm) and plays an important role in angiogenesis cooperating with its ligand vegf. several studies have demonstrated that vegfrs expressed in liquid and solid tumor cells, such as nsclc, melanoma, prostate cancer, leukemia, mesothelioma, and breast cancer and are being regarded as a promising target in clinical [3].zm 306416 is a potent vegfr inhibitor and has a different selectivity with other reported vegfr inhibitors. using a549-egfrb cells for egfrb assay revealed that zm 306416 exhibited inhibitory activity on vegfr with ic50 value of 670 nm [1]. when tested with human thyroid follicular cells, zm 306416 treatment exhibited function on reducing vegfr2 phosphorylation and inhibiting endogenous, steady-state levels of p42/44 mapk phosphorylation [4].
references
1. antczak, c., et al., a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function: implications in drug discovery. j biomol screen, 2012. 17(7): p. 885-99.2. choi kj, baik ih, ye sk et al. molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull. 2015;38(7):986-91. 3. choi, k.j., et al., molecular targeted therapy for hepatocellular carcinoma: present status and future directions. biol pharm bull, 2015. 38(7): p. 986-91.4. susarla, r., j.c. watkinson, and m.c. eggo, regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling. mol cell endocrinol, 2012. 351(2): p. 199-207.
Check Digit Verification of cas no
The CAS Registry Mumber 690206-97-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,2,0 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 690206-97:
(8*6)+(7*9)+(6*0)+(5*2)+(4*0)+(3*6)+(2*9)+(1*7)=164
164 % 10 = 4
So 690206-97-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H13ClFN3O2.ClH/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18;/h3-8H,1-2H3,(H,19,20,21);1H
