690253-79-3Relevant academic research and scientific papers
A facile one-pot synthesis of 2-substituted-3-aminoquinolines: Preparation of benzo[b]naphthyridine-3-carbonitriles
Wang, Yanong D.,Boschelli, Diane H.,Johnson, Steven,Honores, Erick
, p. 2937 - 2942 (2004)
A facile one-pot synthesis of 3-aminoquinolines from ortho- aminobenzaldehydes was developed. Ethyl 6,7-dimethoxy-3-aminoquinoline-2- carboxylate, a key intermediate for the preparation of a 4-anilino-benzo[b][1,5] -naphthyridine-3-carbonitrile, was efficiently prepared by this method. Synthetic routes to 4-anilino-benzo[b][1,5]-naphthyridine-3-carbonitrile and 4-anilino-benzo[b][1,8]-naphthyridine-3-carbonitrile are described.
Tricyclic protein kinase inhibitors
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, (2008/06/13)
This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyro sine kinase and are antiproliferative agents.
