690254-59-2Relevant academic research and scientific papers
Synthetic studies towards furosesquiterpenoids: Total synthesis of (±) desmethylpallescensin-A, (±) isopallescensin-A and (±) isopallescensin-1
Mal, Sajal Kanti,Kar, Gandhi K.,Ray, Jayanta K.
, p. 2805 - 2811 (2007/10/03)
A new approach for a short and efficient synthesis of common cyclohexenone intermediate towards the total synthesis of some furosesquiterpenes and their analogues are described. Regioselective alkylation of Hagemann's ester with 2/3-furyl-2-ethyl bromide followed by hydrolysis cum in situ decarboxylation and 1,4-addition with Gilman's reagent produced the cyclohexanone derivatives which have been utilized for total synthesis of (±) isopallescensin-A, (±) 10-desmethylpallescensin-A, (±) 5-desmethyl-4,5- dehydromicrocionin-1 and (±) isopallescensin-1.
