690261-29-1Relevant academic research and scientific papers
Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
Hall, Adrian,Brown, Susan H.,Budd, Christopher,Clayton, Nicholas M.,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Hurst, David N.,Naylor, Alan,Anthony Rawlings,Scoccitti, Tiziana,Wilson, Alexander W.,Winchester, Wendy J.
, p. 497 - 501 (2011/03/18)
Herein we describe the medicinal chemistry programme to identify a potential back-up compound to the EP1 receptor antagonist GW848687X. This work started with the lipophilic 1,2-biaryl benzene derivative 4 which displayed molecular weight of 41
PHENYL COMPOUNDS AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR
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, (2008/06/13)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such c
PHENYL COMPOUNDS
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, (2008/06/13)
Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R, R, R, R, R, and R are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
