100398-25-2Relevant articles and documents
Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
Hall, Adrian,Brown, Susan H.,Budd, Christopher,Clayton, Nicholas M.,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Hurst, David N.,Naylor, Alan,Anthony Rawlings,Scoccitti, Tiziana,Wilson, Alexander W.,Winchester, Wendy J.
, p. 497 - 501 (2011/03/18)
Herein we describe the medicinal chemistry programme to identify a potential back-up compound to the EP1 receptor antagonist GW848687X. This work started with the lipophilic 1,2-biaryl benzene derivative 4 which displayed molecular weight of 41
Syntheses and bioactivity of o- or p-trifluoromethylphenyl phosphates
Zhou, Xinming,He, Yantao,Wang, Miao,Ding, Yixiang
experimental part, p. 651 - 659 (2009/11/30)
o- and p-Trifluoromethylphenyl phosphates designed as mechanism-based phosphotyrosine phosphatase inactivators have been prepared. Some of them show herbicidal activities.
PYRIDYL COMPOUNDS
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Page/Page column 27, (2008/06/13)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions compris
Discovery of novel biaryl heterocyclic EP1 receptor antagonists
Hall, Adrian,Bit, Rino A.,Brown, Susan H.,Chaignot, Helene M.,Chessell, Iain P.,Coleman, Tanya,Giblin, Gerard M.P.,Hurst, David N.,Kilford, Ian R.,Lewell, Xiao Q.,Michel, Anton D.,Mohamed, Shiyam,Naylor, Alan,Novelli, Riccardo,Skinner, Lee,Spalding, David J.,Tang, Sac P.,Wilson, Richard J.
, p. 2666 - 2671 (2007/10/03)
We describe the generation of novel EP1 receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.
CYCLOHEXENE COMPOUNDS
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Page/Page column 25-26, (2010/02/11)
Formula (I) wherein A, B, Z, R1, R2a , R2b, R8, R9 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
HETEROCYCLYL COMPOUNDS
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Page/Page column 40-41, (2010/02/11)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, D, Z, R1, R2a , R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharm
(2-((2-ALKOXY) -PHENYL) -CYCLOPENT-1-ENYL) AROMATIC CARBO AND HETEROCYCLIC ACID AND DERIVATIVES
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Page/Page column 25, (2010/02/07)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.