690264-31-4

Basic information

• Product Name: Pyridine, 5-(4-chlorophenyl)-2-ethynyl-
• CAS NO: 690264-31-4
• Molecular Formula: C13H8ClN
• Molecular Weight: 213.666
• Mol File: 690264-31-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Pyridine, 5-(4-chlorophenyl)-2-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 5-(4-chlorophenyl)-2-ethynyl-(690264-31-4)
• EPA Substance Registry System: Pyridine, 5-(4-chlorophenyl)-2-ethynyl-(690264-31-4)

Safety Data

• Hazardous Substances Data: 690264-31-4(Hazardous Substances Data)

Upstream product

• 111770-80-0 3-bromo-6-(trimethylsilylethynyl)pyridine 
• 690264-30-3 5-(4-chloro-phenyl)-2-trimethylsilanylethynyl-pyridine 
• 866929-83-1 2-[(tert-butyl-dimethyl-silanyl)-ethynyl]-5-(4-chloro-phenyl)-pyridine 
• 866929-93-3 2-[(tert-butyl-dimethyl-silanyl)-ethynyl]-5-(4-chloro-phenyl)-3-fluoro-pyridine 

Downstream Products

• 690265-95-3 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethanol 
• 690265-96-4 methanesulfonic acid-2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy} ethyl ester 
• 866928-31-6 1-(2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethyl)-4-trifluoromethyl-piperidin-4-ol 
• 690265-84-0 1-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-propan-2-ol 
• 690265-45-3 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-(2-pyrrolidin-1-yl-ethoxy)-benzaldehyde 

Relevant articles and documents

Design, synthesis and evaluation of MCH receptor 1 antagonists - Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Abstract Despite recent approvals of anti-obesity drugs there is still a high therapeutic need for alternative options with higher efficacy in humans. As part of our MCH-R1 antagonist program for the treatment of obesity, a series of biphenylacetamide HTS

NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS COMPRISING SAID COMPOUNDS

The invention relates to individual alkyne compounds with an antagonistic action against the MCH-receptor. Said compounds are suitable for producing medicaments for the treatment of metabolic disorders and/or eating disorders, in particular adiposity and diabetes.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.