6903-07-7Relevant articles and documents
PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS
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Paragraph 00261; 00264; 00270, (2021/12/08)
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).
Efficient synthesis of cannabigerol, grifolin, and piperogalin via alumina-promoted allylation
Jentsch, Nicholas G.,Zhang, Xiong,Magolan, Jakob
, p. 2587 - 2591 (2020/10/12)
The synthesis of three phenolic natural products has been accomplished with unprecedented efficiency using a new alumina-promoted regioselective aromatic allylation reaction. Cannabigerol and grifolin were prepared in one step from the inexpensive 5-alkyl-resorcinols olivetol and orcinol. Piperogalin was synthesized, for the first time, via two sequential allylations of orcinol with geraniol and prenol.
A Novel Synthetic Method of Glifolin and a Pharmaceutical Composition for Prevention or Treatment and Obesity or Diabetes Comprising the Same as an Active Ingredient
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Paragraph 0022-0023; 0025, (2018/08/30)
The present invention relates to a novel synthesis method of grifolin and a pharmaceutical composition containing grifolin as an active ingredient for preventing and treating obesity or diabetes. Particularly, the composition has an effect of inhibiting weight gain, decreasing fat accumulation, decreasing fat cell size, alleviating fatty liver, alleviating blood lipids, decreasing blood glucose and decreasing insulin resistance in an obesity mouse model, thereby exhibiting excellent antiobesity and antidiabetic functions.COPYRIGHT KIPO 2018
Meroterpenoid total synthesis: Conversion of geraniol and farnesol into amorphastilbol, grifolin and grifolic acid by dioxinone-β-keto-acylation, palladium catalyzed decarboxylative allylic rearrangement and aromatization
Ma, Tsz-Kan,White, Andrew J.P.,Barrett, Anthony G.M.
supporting information, p. 2765 - 2767 (2017/06/23)
Biomimetic total syntheses of resorcinols amorphastilbol, grifolin and grifolic acid have been completed in four steps starting from geraniol and farnesol without the use of phenolic protection. The key steps involve C-acylation of dioxinone-β-keto esters, followed by palladium catalyzed decarboxylative allylic rearrangement and biomimetic aromatization.
Studies on the Constituents of Polyporus dispansus and P. confluens
Ishii, Naoyuki,Takahashi, Akira,Kusano, Genjiro,Nozoe, Shigeo
, p. 2918 - 2924 (2007/10/02)
From the lipophilic fraction of fresh Polyporus dispansus, three new farnesylphenols (III,IV,V) and a new isopentenylphenol (VII) were isolated along with grifolin (II), O-methylgrifolin (I) and grifolic acid (VI).The structures of these new compounds wer
ALKYLATION OF ACTIVE HYDROGEN COMPOUNDS WITH ALLYLIC AND BENZYLIC ALCOHOLS UNDER CoCl2 CATALYSIS. A USEFUL SYNTHESIS OF GRIFOLIN
Marquet, J.,Moreno-Manas, M.
, p. 173 - 176 (2007/10/02)
CoCl2 is a useful catalyst for the condensation of allylic and benzylic alcohols with active hydrogen compounds.Under these neutral conditions orcinol and farnesol react to afford the antibiotic grifolin.
