82265-37-0

Upstream product

• 504-15-4 orcinol 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 82280-75-9 C₁₁H₁₅LiO₄ 
• 121287-34-1 2,6-bis(methoxymethyloxy)-4-methylbenzaldehyde 
• 728044-68-6 α-(2,6-dimethyl-1,5-heptadienyl)-2,6-bis(methoxymethoxy)-4-methyl-benzenemethanol 
• 952743-64-5 α-(2,6,10-trimethyl-1,5,9-undecatrienyl)-2,6-bis(methoxymethoxy)-4-methylbenzenemethanol 
• 526-37-4 atranol 
• 6903-07-7 grifolin 
• 121287-17-0 (E)-3-<2,6-bis(methoxymethyloxy)-4-methylphenyl>acrylic acid 
• 121287-18-1 <2,6-bis(methoxymethyloxy)-4-methylphenyl>propionic acid 
• 121287-16-9 1,3-Bis-methoxymethoxy-5-methyl-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene 
• 121287-15-8 (E)-2-(2,6-Bis-methoxymethoxy-4-methyl-benzyl)-3-hydroxy-3,7,11-trimethyl-dodeca-6,10-dienoic acid 
• 121287-22-7 5-Methyl-2-((2Z,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-benzene-1,3-diol 
• 82265-38-1 4-acetoxy-3,5-bis(methoxymethoxy)toluene 
• 1036709-25-7 C₂₆H₄₀O₅ 
• 1207609-84-4 C₂₃H₃₀O₅ 

Relevant academic research and scientific papers

Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities

Natural products have always been an important source of new hits and leads in drug discovery, with the marine environment being regarded as a significant source of novel and exquisite bioactive compounds. Yicathins B and C are two marine-derived xanthones that have shown antibacterial and antifungal activity. Herein, the total synthesis of these yicathins and six novel analogues is reported for the first time. As marine natural products tend to have very lipophilic scaffolds, the lipophilicity of yicathins and their analogues was evaluated in the classical octanol/water system and a biomimetic model-based system. As the xanthonic nucleus is a “privileged structure”, other biological activities were evaluated, namely antitumor and anti-inflammatory activities. An interesting anti-inflammatory activity was identified for yicathin analogues that paves the way for the design of dual activity (anti-infective and anti-inflammatory) marine-inspired xanthone derivatives.

Unusual polycyclic fused product by oxidative enzymatic dimerisation of 5-methylpyrogallol catalysed by horseradish peroxidase/H2O2

During investigations on the peroxidase-catalysed oxidation of polyhydroxylated monoaromatic substrates such as 5-methylpyrogallol, we observed a spectacular dimerisation proceeding by dearomatisation in contrast with most common reaction patterns involvi

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase

African trypanosomiasis is a parasitic disease affecting 5000 humans and millions of livestock animals in sub-Saharan Africa every year. Current treatments are limited, difficult to administer and often toxic causing long term injury or death in many pati

Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence

Described herein is the enantioselective synthesis of multisubstituted biaryl derivatives by chiral phosphoric acid catalyzed asymmetric bromination. Two asymmetric reactions (desymmetrization and kinetic resolution) proceeded successively to afford chiral biaryls in excellent enantioselectivities (up to 99% ee). Both experimental and computational studies suggested that this excellent selectivity could be achieved via a highly organized hydrogen bond network among a substrate, a catalyst (chiral phosphoric acid), and a brominating reagent (N-bromophthalimide).