67988-50-5

Usage

Uses

Used in Pharmaceutical Industry:
2,7-Naphthyridin-1(2H)-one is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of novel drug molecules with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,7-Naphthyridin-1(2H)-one serves as a crucial component in the creation of new agrochemicals, potentially enhancing crop protection and yield through its incorporation into effective and targeted compounds.
Used in Organic Synthesis:
2,7-Naphthyridin-1(2H)-one is utilized as a valuable building block in organic synthesis, enabling the production of a wide range of chemical compounds with diverse applications across various industries.

InChI:InChI=1/C8H6N2O/c11-8-7-5-9-3-1-6(7)2-4-10-8/h1-5H,(H,10,11)

Upstream product

• 5444-01-9 3-cyano-4-methylpyridine 

Downstream Products

• 69042-30-4 1-chloro-[2,7]naphthyridine 
• 1471251-54-3 (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-oxo-2,7-naphthyridin-2(1H)-yl)benzo[d]thiazol-6-yl)acetic acid 
• 858120-63-5 2-benzyl-2H-[2,7]naphthyridine-1-one 
• 253-45-2 [2,7]naphthyridine 
• 86278-61-7 1-bromo-2,7-naphthyridine 
• 959558-27-1 4-bromo-1,2-dihydro-2,7-naphthyridin-1-one 
• 1345044-53-2 1-chloro-4-phenyl-[2,7]naphthyridine 
• 1234616-02-4 1-chloro-4-iodo-2,7-diazanaphthalene 
• 959558-50-0 4-iodine-2,7-naphthyridine-1(2H)-one 
• 1706749-51-0 4-bromo-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one 

Relevant academic research and scientific papers

IN-FLOW PHOTOOXYGENATION OF AMINOTHIENOPYRIDINONES GENERATES NOVEL PTP4A3 PHOSPHATASE INHIBITORS

The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

A 2, 7-naphthyridine-based fluorescent turn-on probe for detection of biothiols in vitro and in vivo

A 2,7-naphthyridine derivative (AND-OH) was used as a fluorophore in the development of a novel fluorescent turn-on probe (AND-DNBS) by introducing a 2,4-dinitrobenzenesulfonate functionality. This fluorescent probe was successfully used for sensing glutathione (GSH) in aqueous media and showed favorable properties such as a rapid response time (45 s) and a significant Stokes shift (227 nm). The characteristics of the developed probe are better than those of another probe, namely ND-DNBS, which was also synthesized by our group and most other previously reported fluorescent probes for GSH. The AND-DNBS probe was able to detect GSH via a red emission in living A549 cells and zebrafishes. These results show that AND-DNBS has potential applications as an excellent probe for detecting GSH in various environments.

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatographic purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model.

PYRIDINE DERIVATIVES, METHODS OF THEIR PREPARATIONS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention relates to pyridine derivatives having inhibitory effects on synthesis of cytokines, which are involved in inflammatory reactions, thus being useful as a therapeutic agent for treatment of inflammation-related diseases, immune-related diseases and chronic inflammatory diseases methods as well as an anti-inflammatory and analgesic agent, methods for their preparations, and pharmaceutical compositions containing the same.