69047-43-4Relevant academic research and scientific papers
Late-Stage Diversification of Biarylphosphines through Rhodium(I)-Catalyzed C-H Bond Alkenylation with Internal Alkynes
Zhang, Zhuan,Cordier, Marie,Dixneuf, Pierre H.,Soulé, Jean-Fran?ois
supporting information, p. 5936 - 5940 (2020/07/30)
We report herein P(III)-directed C-H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)]2 acts as a better catalyst than commercially available [RhCl(COD)]2. Conditions were developed to control the mono- and difunctionalization depending on the alkyne stoichiometry. One of these novel bisalkenylated (dialkyl)biarylphosphines was employed for the preparation of a palladium(II) complex, and some of these functionalized ligands outperformed their corresponding unfunctionalized phosphines in Pd-catalyzed amidation with sterically hindered aryl chlorides.
Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
Lourenco, Maria Cristina Silva,Vicente, Felipe Rodrigues,Henriques, Maria das Gracas Muller de Oliveira,Peixoto Candea, Andre Luis,Borges Goncalves, Raoni Schroeder,Nogueira, Thais Cristina M.,de Lima Ferreira, Marcelle,Nora de Souza, Marcus Vinicius
, p. 6895 - 6898 (2008/03/14)
The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concen
