Late-Stage Diversification of Biarylphosphines through Rhodium(I)-Catalyzed C-H Bond Alkenylation with Internal Alkynes
We report herein P(III)-directed C-H bond alkenylation of (dialkyl)- and (diaryl)biarylphosphines using internal alkynes. Chloride-free [Rh(OAc)(COD)]2 acts as a better catalyst than commercially available [RhCl(COD)]2. Conditions were developed to control the mono- and difunctionalization depending on the alkyne stoichiometry. One of these novel bisalkenylated (dialkyl)biarylphosphines was employed for the preparation of a palladium(II) complex, and some of these functionalized ligands outperformed their corresponding unfunctionalized phosphines in Pd-catalyzed amidation with sterically hindered aryl chlorides.
Zhang, Zhuan,Cordier, Marie,Dixneuf, Pierre H.,Soulé, Jean-Fran?ois
supporting information
p. 5936 - 5940
(2020/07/30)
Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concen
Lourenco, Maria Cristina Silva,Vicente, Felipe Rodrigues,Henriques, Maria das Gracas Muller de Oliveira,Peixoto Candea, Andre Luis,Borges Goncalves, Raoni Schroeder,Nogueira, Thais Cristina M.,de Lima Ferreira, Marcelle,Nora de Souza, Marcus Vinicius
p. 6895 - 6898
(2008/03/14)
A New Reagent for Activating Carboxyl Groups; Preparation and Reactions of N,N-Bisphosphorodiamidic Chloride
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Diago-Meseguer, J.,Palomo-Coll, A.L.,Fernandez-Lizarbe, J.R.,Zugaza-Bilbao, A.
p. 547 - 551
(2007/10/02)
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