690660-82-3

Basic information

• Product Name: (E)-6-oxo-6-phenylhex-4-enenitrile
• Synonyms: (E)-6-oxo-6-phenylhex-4-enenitrile
• CAS NO: 690660-82-3
• Molecular Weight: 185.225
• Mol File: 690660-82-3.mol

Chemical Properties

• CAS DataBase Reference: (E)-6-oxo-6-phenylhex-4-enenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-oxo-6-phenylhex-4-enenitrile(690660-82-3)
• EPA Substance Registry System: (E)-6-oxo-6-phenylhex-4-enenitrile(690660-82-3)

Safety Data

• Hazardous Substances Data: 690660-82-3(Hazardous Substances Data)

Upstream product

• 152858-50-9 6-phenyl-5-hexyne-1-nitrile 
• 3515-93-3 4-oxobutanenitrile 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 

Downstream Products

• 690660-91-4 (2-amino-5-ethyl-cyclopent-1-enyl)-phenyl-methanone 

Relevant articles and documents

Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

A gold-catalyzed oxidative cyclization of alkyne-nitriles using water or alcohol as the external nucleophiles has been developed. The catalytic system, featured with gold and Lewis acid dual catalysis, allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines with a wide structural diversity. This journal is

Copper-Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters, and Nitriles as Terminal Electrophiles

Exposure of enone substrates 1a?18a, which possess appendant ketone, ester, and nitrile moieties, to Et2Zn in the presence of catalytic Cu(OTf)2/P(OEt)3 provides the cyclized products in good to excellent yields and diastereoselectivities. These results represent the first use of ketones, esters, and nitriles as terminal electrophiles in Cu-catalyzed conjugate addition?electrophilic trapping. Copyright