690674-19-2

Upstream product

• 561327-31-9 (R)-2-(benzyloxymethyl)-4-methylpentan-1-ol 
• 163810-26-2 (4R)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one 
• 100-59-4 phenylmagnesium chloride 
• 690674-34-1 (azidomethyl)[(S)-2-(benzyloxymethyl)-4-methylpentyl]diphenylsilane 
• 690674-36-3 [[[(S)-2-(benzyloxymethyl)-4-methylpentyl]diphenylsilanyl]methyl]amine 
• 503066-37-3 (S)-[2-(benzyloxymethyl)-4-methylpentyl](chloromethyl)diphenylsilane 
• 503066-44-2 (R)-4-benzyl-3-[(S)-2-(benzyloxymethyl)-4-methylvaleroyl]oxazolidin-2-one 
• 503066-45-3 (S)-2-(benzyloxymethyl)-1-iodo-4-methylpentane 
• 503066-36-2 (chloromethyl)fluorodiphenylsilane 

Relevant academic research and scientific papers

A Silanediol Inhibitor of the Metalloprotease Thermolysin: Synthesis and Comparison with a Phosphinic Acid Inhibitor

A silanediol inhibitor of the metalloprotease thermolysin was prepared for comparison to a known phosphinic acid inhibitor, providing the first comparison of these second-row element based transition-state analogues. Inhibition of thermolysin by the silanediol (Ki = 41 nM) was comparable to that of the phosphinic acid (Ki = 10 nM) even though the silanediol is uncharged and thereby lacks the intrinsic Coulombic attraction of the phosphinate anion to the active-site zinc cation. This silanediol protease inhibitor is the least sterically encumbered example prepared to date and, therefore, the most prone toward polymerization. Hydrolysis of a difluorosilane intermediate to the silanediol leads cleanly to a monomeric product.