69068-64-0Relevant academic research and scientific papers
Acetals moiety contained pH-sensitive amphiphilic copolymer self-assembly used for drug carrier
Lu, Jushan,Li, Najun,Xu, Qingfeng,Ge, Jianfeng,Lu, Jianmei,Xia, Xuewei
, p. 1709 - 1715 (2010)
pH-sensitive nanoparticles were prepared from a novel amphiphilic copolymer poly(2-phenyl-1, 3-dioxan-5-yl methacrylate-co-2-hydroxyethyl acrylate), poly(PDM-co-HEA), which was synthesized from the pH-sensitive hydrophobic monomer 2-phenyl-1, 3-dioxan-5-yl methacrylate (PDM) and the hydrophilic monomer 2-hydroxyethyl acrylate (HEA) with unit ratio (4:6) via radical polymerization. The random amphiphilic polymer could form nanoparticles in aqueous media with sizes of about 167?nm (PDI?=?0.03). The morphology of the nanoparticles was determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM). When the nanoparticles solution was adjusted to pH?=?5.5, sizes of the nanoparticles increased from 167?nm to about 800?nm within 24?h, characterized by DLS. The critical aggregation concentration (CAC) of the copolymer was determined to be 5.3?mg/L (1.7?×?10-7?M). The insoluble Nile Red could be delivered into the Hep3B cells by the nanoparticles and released in cytoplasm determined by fluorescence microscopy.
