69076-65-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(4-pyridinyl)-
• CAS NO: 69076-65-9
• Molecular Formula: C13H8N2O2
• Molecular Weight: 224.219
• Mol File: 69076-65-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-pyridinyl)-(69076-65-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(4-pyridinyl)-(69076-65-9)

Safety Data

• Hazardous Substances Data: 69076-65-9(Hazardous Substances Data)

Usage

Structure

Isoindole derivative with a pyridine ring

Usage

Production of pharmaceuticals, agrochemicals, potential applications in materials science and organic synthesis

Safety

Handle with care and follow proper safety protocols to avoid health and environmental hazards.

Upstream product

• 504-24-5 4-aminopyridine 
• 85-44-9 phthalic anhydride 

Downstream Products

• 176695-08-2 2,3-dihydro-1-hydroxy-1-phenyl-2-(pyridin-4-yl)-1H-isoindole 
• 3532-43-2 3-hydroxy-3-phenyl-2-pyridin-4-yl-2,3-dihydro-isoindol-1-one 

Relevant articles and documents

Ru-Catalyzed Selective C-H Bond Hydroxylation of Cyclic Imides

We report on cyclic imides as weak directing groups for selective monohydroxylation reactions using ruthenium catalysis. Whereas acyclic amides are known to promote the hydroxylation of the C(sp2)-H bond enabling five-membered ring ruthenacycle intermediates, the cyclic imides studied herein enabled the hydroxylation of the C(sp2)-H bond via larger six-membered ruthenacycle intermediates. Furthermore, monohydroxylated products were exclusively obtained (even in the presence of overstoichiometric amounts of reagents), which was rationalized by the difficulty to accommodate coplanar intermediates once the first hydroxyl group was introduced into the substrate. The same reactivity was observed in the presence of palladium catalysts.