69084-00-0Relevant academic research and scientific papers
Design, synthesis and evaluation of the antioxidant and neuroprotective properties of alkyl- and terpenylphenolchlorin conjugates
Chukicheva, I. Yu.,Buravlev,Belykh,Khudyaeva,Fedorova,Shevchenko,Maximova,Zainullina,Vakhitova, Yu. V.,Kutchin
, p. 548 - 557 (2018)
The new amide conjugates were synthesized from methyl pheophorbide a and its carboxyl derivatives by reactions with aminomethyl derivatives of 2,4-dimethylphenol, 2-isocamphyl-4- methylphenol, 2-bornyl-4-methylphenol, and 2-isobornyl-4-methylphenol. The antioxidant activity of some conjugates was established by investigation of their ability to inhibit the accumulation of secondary products of lipid peroxidation in a brain of laboratory mice in vitro. The neuroprotective properties of porphyrin and terpenylphenol conjugates have been studied on the model of H2O2-induced oxidative stress in SH-SY5Y cells (neuroblastoma).
Microwave-assisted aminomethylation of electron-rich compounds under solvent-free condition
Mojtahedi, Mohammad M.,Sharifi, Ali,Mohsenzadeh, Farshid,Saidi, Mohammad R.
, p. 69 - 72 (2007/10/03)
Electron-rich aromatic compounds react with formaldehyde and a secondary amine under solvent-free condition, in the presence of acidic alumina in a commercial microwave oven or at room temperature to produce aminomethylated products in good to excellent yields.
The activation of aminals and aminol ethers by sulfur dioxide and their reactions with electron rich aromatic compounds
Heaney, Harry,Papageorgiou, George,Wilkins, Robert F.
, p. 13361 - 13372 (2007/10/03)
Reactions of bis(dialkylamino)methanes and ethoxydialkylaminomethanes with nucleophilic aromatic heterocycles in the presence of sulfur dioxide result in the formation of the expected Mannich bases in good yields. Reactions of phenols are similarly activated by sulfur dioxide which lead to improved regioselectivity: in particular the reactions of 2,5-dimethylphenol result in the formation of 2-dialkylaminomethyl-3,6-dimethylphenol whereas reaction occurs at the I-position using the classical procedures.
THE EFFECT OF SULPHUR DIOXIDE ON THE MANNICH REACTIONS OF PHENOLS
Fairhurst, Robin A.,Heaney, Harry,Papageorgiou, George,Wilkins, Robert F.
, p. 5801 - 5804 (2007/10/02)
Regioselectivity in the ortho-dialkylaminomethylation of phenols in greatest, for example in reactions of 2,5-dimethylphenol, when a mixture of the phenol and sulphur dioxide is allowed to stand for several hours before the addition of a bis-(dialkylamino)methane (aminal) or an alkoxydialkylaminomethane (aminol ether).
