69095-72-3

Usage

InChI:InChI=1/C16H15N3O/c1-11-6-3-4-9-14(11)16-17-15(18-19-16)12-7-5-8-13(10-12)20-2/h3-10H,1-2H3,(H,17,18,19)

Upstream product

• 7658-80-2 2-methylbenzohydrazide 
• 1527-89-5 3-methoxybenzonitrile 
• 118-90-1 ortho-methylbenzoic acid 
• 933-88-0 ortho-toluoyl chloride 

Relevant academic research and scientific papers

Acyl-1H-1,2,4-triazole derivatives

New acyl-1H-1,2,4-triazole derivatives of the formula STR1 wherein R may be located on one of the two adjacent nitrogen atoms and may represent hydrogen; a group R5 -CO wherein R5 is selected from (C1-4)alkyl, (C2-4/

Reaction of Substituted Acid Hydrazides with Substituted Benzonitriles: Formation of Isomeric Triazoles

The reaction of substituted benzoic acid hydrazides with substituted benzonitriles yields besides 3,5-di(substituted phenyl)-4H-1,2,4 (5-8)- and -1H-1,2,4 (1-4)-triazoles, the 2,5-di(substituted phenyl)-1,3,4-oxadiazoles (9-12).

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.

3,5-Disubstituted-1H-1,2,4-triazole derivatives as antifertility agents

New 3,5-disubstituted-1H-1,2,4-triazoles of formula STR1 wherein: R is selected from hydrogen, (C1-4)alkyl, (C1-4)alkoxy, allyloxy, propargyloxy, trifluoromethyl, phenyl, fluoro, chloro and dimethylamino; R1 represents a (C1-4)alkyl group; R2 is selected from hydrogen, fluoro, chloro, (C1-4)alkyl, methoxy and ethoxy; R3 is selected from hydrogen, fluoro, chloro, (C1-4)alkyl and (C1-4)alkoxy; R and R3 taken together represent a methylenedioxy group; with the proviso that, when simultaneously R, R2 and R3 represent hydrogen, cannot be methyl; with the further proviso that, when simultaneously R2 and one of R and R3 represent hydrogen, R1 and the other of R and R3 cannot simultaneously represent methyl; and salts therewith of pharmaceutically acceptable acids. The compounds possess anti-reproductive utility.

3,5-Disubstituted-1H-1,2,4-triazole derivatives

New 3,5-disubstituted 1H-1,2,4-triazoles of formula I STR1 wherein: R is selected from hydrogen, (C1-4)alkyl, (C1-4)alkoxy, allyloxy, propargyloxy, trifluoromethyl, phenyl, fluoro, chloro and dimethylamino; R1 represents a