690963-48-5Relevant academic research and scientific papers
Arylalkyl substituted imidazolidinones
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Page/Page column 7, (2009/09/07)
New compounds of formula (I), wherein: R1, R2, R3, R4 and R5 are, independently from each other, hydrogen; C1-6alkyl; aryl; heteroaryl and perhaloalkyl, and wherein at least one of R1 and R2 is different from hydrogen; n is 0 or 1; R6 is hydrogen or C1-6
New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies
Sundriyal, Sandeep,Viswanad, Bhoomi,Bharathy, Elumalai,Ramarao, Poduri,Chakraborti, Asit K.,Bharatam, Prasad V.
scheme or table, p. 3192 - 3195 (2009/04/06)
FlexX-based molecular docking study was employed to identify 2-hydroxy-1,4-naphthoquinone as a new 'acidic head group' for the design of a novel series of PPARγ ligands. To provide the proof of concept, designed molecules were synthesized and evaluated in a standard radioligand-binding assay. Out of eight molecules, four were found to bind to the murine PPARγ with IC50 ranging from 0.2 to 56.2 μM as compared to standard pioglitazone, with IC50 of 0.7 μM.
