851547-40-5

Upstream product

• 41661-47-6 piperidin-4-one 
• 851547-27-8 4-bromo-2-(bromomethyl)-1-[(4-chlorophenyl)methoxy]benzene 
• 1761-61-1 5-bromosalicyclaldehyde 
• 428482-55-7 5-bromo-2-((4-chlorobenzyl)oxy)benzaldehyde 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 690965-23-2 [5-bromo-2-(4-chloro-benzyloxy)-phenyl]-methanol 

Downstream Products

• 851550-31-7 4-(aminomethyl)-1-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-4-piperidinol 
• 851550-30-6 6-[[5-bromo-2-[(4-chlorophenyl)methoxy]phenyl]methyl]-1-oxa-6-azaspiro[2.5]octane 

Relevant academic research and scientific papers

CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives

The guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde, 1, with an IC50 of 840 nM against the CCR5 receptor was identified using high-throughput screening. Optimization efforts led to the discovery of a novel piperidine series of CCR5