691-80-5

Basic information

• Product Name: CHLOROAC-ALA-OH
• Synonyms: CHLOROACETYL-L-ALANINE;CHLOROAC-ALA-OH;CLAC-ALA-OH;N-CHLOROACETYL-L-ALA
• CAS NO: 691-80-5
• Molecular Formula: C₅H₈ClNO₃
• Molecular Weight: 165.57
• Mol File: 691-80-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 401.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.341±0.06 g/cm3(Predicted)
• PKA: 3.26±0.10(Predicted)
• CAS DataBase Reference: CHLOROAC-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROAC-ALA-OH(691-80-5)
• EPA Substance Registry System: CHLOROAC-ALA-OH(691-80-5)

Safety Data

• Hazardous Substances Data: 691-80-5(Hazardous Substances Data)

Usage

General Description

Chloroac-Ala-OH is a synthetic compound and a derivative of the amino acid alanine. It is a chloroacetic acid ester of alanine and is often used as a building block in peptide and protein synthesis. CHLOROAC-ALA-OH is typically utilized in the modification and design of functional peptides and as a chemical tool in the study of protein-ligand interactions. Chloroac-Ala-OH has the potential to serve as an important agent in the development of therapeutic drugs and pharmaceuticals due to its ability to induce biological responses and interact with various biological targets.

Upstream product

• 27243-15-8 N-succinimidyl 2-chloroacetate 
• 56-41-7 L-alanin 
• 79-11-8 chloroacetic acid 
• 3695-73-6 glycyl-L-alanine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 82283-68-9 C₅H₇NO₆P^(3-)*3Na⁽¹⁺⁾ 
• 87823-49-2 3(S)-methylmorpholine-2,5-dione 
• 127094-71-7 (3S)-3-methylmorpholine-2,5-dione 
• 1474030-26-6 (S)-2-[2-(phenylselenyl)acetamido]propanoic acid 
• 1417521-30-2 (S)-S-phenyl 2-(2-azidoacetamido)propanethioate 

Relevant articles and documents

CROSSLINKED POLY-DEPSIPEPTIDE COPOLYMERS AND METHODS OF MAKING THEREOF

Aspects of the present disclosure include methods for preparing crosslinked polydepsipeptide copolymers by stereolithography (e.g., 3-D printing). In practicing methods according to certain embodiments, a crosslinkable copolymer containing a depsipeptide

Biodegradable photocrosslinkable poly(depsipeptide-co-caprolactone) for tissue engineering: Synthesis, characterization, and in vitro evaluation

Stereolithography has become increasingly popular in scaffold fabrication due to automation and well-controlled geometry complexity, and consequently, there is a great need for new suitable biodegradable photocrosslinkable polymers. In this study, a new type of photocrosslinkable poly(ester amide) was synthesized based on e-caprolactone and L-alaninederived depsipeptide and was applied to fabrication of threedimensional (3D) scaffolds by stereolithography. 1H nuclear magnetic resonance and Fourier transform infra-red analysis confirmed the formation of new bonds during the polymer synthesis. Incorporation of depsipeptide increased the glass transition temperature and hydrophilicity of the polymer and accelerated hydrolytic degradation compared with the poly(ecaprolactone) homopolymer. The compressive strength of the 3D scaffolds increased with the increasing depsipeptide content. This work demonstrated that incorporation of depsipeptide into photocrosslinkable polyesters resulted in excellent cytocompatibility and tunable degradation rates and mechanical properties and thus expanded the repertoire of biomaterials suitable for 3D photofabrication of high-resolution tissue engineering scaffolds.

Efficient synthesis of 2,5-diketopiperazines by Staudinger-mediated cyclization

Solution- and solid-phase Staudinger-mediated cyclizations were assessed to efficiently prepare hetero-2,5-diketopiperazines from their protected azido dipeptide thioesters under microwave irradiation. Short reaction time, good yields and ease of purification are the main assets of this methodology. Georg Thieme Verlag Stuttgart · New York.