691008-14-7

Downstream Products

• 691007-90-6 2-Chlorobenzyl 4-cyano-5-[(2-ethylbutanoyl)amino]-3-methylthiophene-2-carboxylate 
• 691007-99-5 4-cyano-N-cyclopentyl-5-[(2-ethylbutanoyl)amino]-N-(4-fluorobenzyl)-3-methylthiophene-2-carboxamide 
• 691007-98-4 N-benzyl-4-cyano-N-ethyl-5-[(2-ethylbutanoyl)amino]-3-methylthiophene-2-carboxamide 
• 880158-96-3 N-{5-[({[(1Z)-1-amino-2-(2,4-dichlorophenyl)ethylidene]amino}oxy)carbonyl]-3-cyano-4-methyl-2-thienyl}-2-ethylbutanamide 

Relevant academic research and scientific papers

Cyanothiophene derivatives, compositions containing such compounds and methods of use

The present invention addresses substituted cyanothiophene derivatives of the formula I: as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.