880158-96-3Relevant academic research and scientific papers
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
Cohen, Sheila M.,Duffy, Joseph L.,Miller, Corin,Kirk, Brian A.,Candelore, Mari Rios,Ding, Victor D. H.,Kaczorowski, Gregory,Tota, Laurie M.,Werrmann, Jeffrey G.,Wright, Michael,Parmee, Emma R.,Tata, James R.,Zhang, Bei B.
, p. 1506 - 1517 (2006)
The demonstration of pharmacodynamic efficacy of novel chemical entities represents a formidable challenge in the early exploration of synthetic lead classes. Here, we demonstrate a technique to validate the biological efficacy of novel antagonists of the
