6911-92-8

Basic information

• Product Name: N-(4-methylphenyl)-3-nitrobenzamide
• Synonyms: benzamide, N-(4-methylphenyl)-3-nitro-
• CAS NO: 6911-92-8
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.2567
• Mol File: 6911-92-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 340.1°C at 760 mmHg
• Flash Point: 159.5°C
• Density: 1.304g/cm³
• Vapor Pressure: 8.77E-05mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: N-(4-methylphenyl)-3-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-3-nitrobenzamide(6911-92-8)
• EPA Substance Registry System: N-(4-methylphenyl)-3-nitrobenzamide(6911-92-8)

Safety Data

• Hazardous Substances Data: 6911-92-8(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 121-92-6 3-nitrobenzoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 645-00-1 m-iodonitrobenzene 
• 3085-54-9 N-(4-methylphenyl)formamide 
• 99-08-1 1-methyl-3-nitrobenzene 
• 726-42-1 di-p-tolylcarbodiimide 
• 32578-25-9 trifluoromethanesulfonic acid 3-nitrophenyl ester 
• 621-00-1 1,3-di-p-tolylurea 

Downstream Products

• 645-09-0 3-nitrobenzamide 
• 6393-42-6 4-methyl-2,6-dinitroaniline 
• 860566-26-3 3-nitro-benzoic acid-(4-methyl-2,6-dinitro-anilide) 
• 14315-26-5 3-amino-N-(4-tolyl)benzamide 

Relevant articles and documents

CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation

A magnetite-reduced graphene oxide-supported CuO nanocomposite (rGO/Fe3O4-CuO) was preparedviaa facile chemical method and characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Brunauer-Emmett-Teller (BET) analysis, vibrating-sample magnetometry (VSM), and thermogravimetric (TG) analysis. The catalytic activity of the rGO/Fe3O4-CuO nanocomposite was probed in the direct oxidative amidation reaction of methylarenes with free amines. Various aromatic and aliphatic amides were prepared efficiently at room temperature from cheap raw chemicals usingtert-butyl hydroperoxide (TBHP) as a “green” oxidant and low-toxicity TBAI in water. This method combines the oxidation of methylarenes and amide bond formation into a single operation. Moreover, the synthesized nanocomposites can be separated from the reaction mixtures using an external magnet and reused in six consecutive runs without a noticeable decrease in the catalytic activity.

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with 2,4,6-Trichloro-1,3,5-triazine/Formamide Mixed Reagent

In this work, the mixture of formamide and 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride or TCT) is introduced as a new amidating agent in Pd-catalyzed aminocarbonylation of aryl halides. In the presence of a catalytic amount of palladium and TCT/formamide reagent, a range of aryl halides (X = Cl, Br, I) were converted into amides efficiently in N,N-dimethylformamide at 120 °C. The 2,4,6-trichloro-1,3,5-triazine/formamide mixed reagent was found to be an efficient amidating agent in Pd-catalyzed aminocarbonylation of aryl halides. In the presence of this reagent and a catalytic amount of Pd, a range of amides were synthesized by using aryl halides.

Direct oxidative amidation of aldehydes with anilines under mechanical milling conditions

(Chemical Equation Presented) Oxone is found to be an effective oxidant for the oxidative amidation of aldehydes with anilines to furnish amides in a one-pot process under mechanical milling conditions.