32578-25-9

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 3-nitrophenyl ester
• CAS NO: 32578-25-9
• Molecular Formula: C7H4F3NO5S
• Molecular Weight: 271.174
• Mol File: 32578-25-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 3-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 3-nitrophenyl ester(32578-25-9)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 3-nitrophenyl ester(32578-25-9)

Safety Data

• Hazardous Substances Data: 32578-25-9(Hazardous Substances Data)

Upstream product

• 1493-13-6 trifluorormethanesulfonic acid 
• 586-36-7 3-nitrophenyldiazonium tetrafluoroborate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 1044209-74-6 C₁₃H₁₂N₂O₃ 
• 24933-39-9 (difluoromethyl)(3-nitrophenyl)thioether 
• 50445-53-9 N-isopropyl-3-nitrobenzamide 
• 6911-92-8 3-nitro-N-(p-tolyl)benzamide 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 1359844-19-1 C₁₅H₂₃I 
• 1359844-18-0 C₁₁H₁₅I 
• 1359844-14-6 3-nonylphenylboronic acid 
• 1359844-13-5 3-pentylphenylboronic acid 
• 1359844-21-5 4,4,5,5-tetramethyl-2-(3-nonylphenyl)-1,3,2-dioxaborolane 
• 1359844-09-9 pinacol(3-pentylphenyl)boronate 
• 1359844-23-7 C₁₅H₂₃BF₃^(1-)*K⁽¹⁺⁾ 
• 1359844-22-6 C₁₁H₁₅BF₃^(1-)*K⁽¹⁺⁾ 
• 57335-98-5 3-pentylphenylamine 

Relevant articles and documents

Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors

The Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor erythroid 2-related factor 2)-ARE (antioxidant response element) pathway is the major defending mechanism against oxidative stresses, and directly disrupting the Keap1-Nrf2 protein-protein interaction (PPI) has been an attractive strategy to target oxidative stress-related diseases, including cardiovascular diseases. Here, we describe the design, synthesis, and structure-activity relationships (SARs) of indoline-based compounds as potent Keap1-Nrf2 PPI inhibitors. Comprehensive SAR analysis and thermodynamics-guided optimization identified 19a as the most potent inhibitor in this series, with an IC50 of 22 nM in a competitive fluorescence polarization assay. Further evaluation indicated the proper drug-like properties of 19a. Compound 19a dose-dependently upregulated genes and protein level of Nrf2 as well as its downstream markers and showed protective effects against lipopolysaccharide-induced injury in both H9c2 cardiac cells and mouse models. Collectively, we reported here a novel indoline-based Keap1-Nrf2 PPI inhibitor as a potential cardioprotective agent.

Pd-Catalyzed Difluoromethylthiolation of Aryl Chlorides, Bromides and Triflates

A highly efficient Pd-catalyzed difluoromethylthiolation of aryl chlorides, bromides and triflates is described. A variety of aryl halides with common functional groups were difluoromethylthiolated in moderate to excellent yields. Furthermore, several nat

The conversion of phenols to the corresponding aryl halides under mild conditions

Mild, novel procedures have been developed for the syntheses of aryl halides from the corresponding phenols in modest to good yields via boronate ester intermediates.