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69123-55-3

1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 69123-55-3 Structure

  • Basic information

    1. Product Name: 1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea
    2. Synonyms: urea, N-(4-chlorophenyl)-N'-2-thiazolyl-
    3. CAS NO:69123-55-3
    4. Molecular Formula: C10H8ClN3OS
    5. Molecular Weight: 253.708
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 69123-55-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.542g/cm3
    6. Refractive Index: 1.741
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea(69123-55-3)
    11. EPA Substance Registry System: 1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea(69123-55-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 69123-55-3(Hazardous Substances Data)

69123-55-3 Usage

Type of Compound

Chemical compound

Potential Applications

Treatment of various diseases, such as cancer and autoimmune disorders

Mechanism of Action

Potent and selective inhibitor of the enzyme Pim-1 (serine/threonine kinase)

Role of Pim-1

Involved in cell proliferation, survival, and apoptosis

Effect on Cancer Cells

Inhibits growth and induces apoptosis

Potential as Cancer Therapy

Promising candidate

Investigation for Autoimmune Diseases

Modulates T cell responses

Significance in Medical Research

Valuable compound for drug development and understanding disease mechanisms

Check Digit Verification of cas no

The CAS Registry Mumber 69123-55-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,1,2 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 69123-55:
(7*6)+(6*9)+(5*1)+(4*2)+(3*3)+(2*5)+(1*5)=133
133 % 10 = 3
So 69123-55-3 is a valid CAS Registry Number.

69123-55-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-chlorophenyl)-3-(1,3-thiazol-2-yl)urea

1.2 Other means of identification

Product number -
Other names HMS2361F10

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:69123-55-3 SDS

69123-55-3Downstream Products

69123-55-3Relevant articles and documents

Selenium-catalyzed carbonylation of 2-aminothiazole with nitro aromatics to N-aryl-N′-2-thiazolylureas

Zhang, Xiaopeng,Tang, Zhaojing,Niu, Xueli,Li, Zhengwei,Fan, Xuesen,Zhang, Guisheng

supporting information, p. 5266 - 5270 (2016/11/11)

An efficient, economical, and phosgene-free procedure for the synthesis of N-aryl-N′-2-thiazolylureas is reported. With cheap and recyclable nonmetal selenium instead of noble metals as the catalyst, carbon monoxide instead of virulent phosgene as the carbonylation agent, the selenium-catalyzed carbonylation reaction of 2-aminothiazole can proceed smoothly in one-pot manner with a variety of nitro aromatics in the presence of triethylamine to afford the desired N-aryl-N′-2-thiazolylureas mostly in moderate to good yields. Selenium catalyst can be easily recovered due to its phase-transfer catalytic ability and reused without any significant degradation of its catalytic performance.

Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-parkinsonian agents

Azam, Faizul,Shrivastava, Anil Kumar,Mohan, Govind,Prasad, Medapati Vijaya Vara,Thangavel, Neelaveni

, p. 1057 - 1068,12 (2012/12/12)

Synthesis of 1-(substituted aryl)-3-(thiazol-2-yl)urea derivatives was undertaken as our efforts to discover novel antiparkinsonian agents with improved pharmacological profile in haloperidol-induced catalepsy and oxidative stress in mice. Furfuryl, 2- an

Structure-based design, synthesis and molecular modeling studies of thiazolyl urea derivatives as novel anti-parkinsonian agents

Azam, Faizul,Prasad, Medapati Vijaya Vara,Thangavel, Neelaveni,Shrivastava, Anil Kumar,Mohan, Govind

, p. 1057 - 1068 (2013/01/15)

Synthesis of 1-(substituted aryl)-3-(thiazol-2-yl)urea derivatives was undertaken as our efforts to discover novel antiparkinsonian agents with improved pharmacological profile in haloperidol-induced catalepsy and oxidative stress in mice. Furfuryl, 2- an

Study of structural parameters related to anthelminthic activity of thiazole derivatives

Walchshofer,Minjat,Tinland,et al.

, p. 59 - 64 (2007/10/02)

Thiazole derivatives were synthesized and their anthelminthic activity was tested against a nematode and cestode. The effect of electronic parameters, lipophilicity and biotransformation on activity is discussed.

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